Gene Symbol | CTU2 |
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Entrez Gene | 348180 |
Alt Symbol | C16orf84, NCS2, UPF0432 |
Species | Human |
Gene Type | protein-coding |
Description | cytosolic thiouridylase subunit 2 homolog (S. pombe) |
Other Description | cytoplasmic tRNA 2-thiolation protein 2 |
Swissprots | Q66K78 Q86SV4 Q0P511 B2RXK0 Q6P4C8 Q2VPK5 |
Accessions | EAW66775 EAW66776 EAW66777 EAW66778 EAW66779 EAW66780 Q2VPK5 AK299521 BAG61472 BC021056 BC021829 BC044951 BC063512 BC080540 AAH80540 BC108659 AAI08660 BC121805 AAI21806 BC125269 AAI25270 BC157881 AAI57882 BM554780 BQ430809 XM_011523068 XP_011521370 NM_001012759 NP_001012777 NM_001012762 NP_001012780 |
Function | Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. {ECO:0000255|HAMAP-Rule:MF_03054, ECO:0000269|PubMed:19017811}. |
Subcellular Location | Cytoplasm. |
Top Pathways | Sulfur relay system |
CTU2 CRISPR/Cas9 KO Plasmid (h) - sc-415645 from Santa Cruz Biotechnology
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CTU2 HDR Plasmid (h) - sc-415645-HDR from Santa Cruz Biotechnology
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CTU2 Double Nickase Plasmid (h) - sc-415645-NIC from Santa Cruz Biotechnology
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CTU2 Double Nickase Plasmid (h2) - sc-415645-NIC-2 from Santa Cruz Biotechnology
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CTU2 CRISPR Activation Plasmid (h) - sc-415645-ACT from Santa Cruz Biotechnology
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CTU2 CRISPR Activation Plasmid (h2) - sc-415645-ACT-2 from Santa Cruz Biotechnology
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CTU2 Lentiviral Activation Particles (h) - sc-415645-LAC from Santa Cruz Biotechnology
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CTU2 Lentiviral Activation Particles (h2) - sc-415645-LAC-2 from Santa Cruz Biotechnology
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CTU2 siRNA (h) - sc-93162 from Santa Cruz Biotechnology
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CTU2 shRNA Plasmid (h) - sc-93162-SH from Santa Cruz Biotechnology
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CTU2 shRNA (h) Lentiviral Particles - sc-93162-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU031191 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN6765 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND6765 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00267 from Sigma-Aldrich
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CTU2 siRNA (Human) - CRJ7530 from Cohesion Biosciences
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CTU2 - MBS8233121 from MyBioSource
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shRNA set against Human CTU2 (NM_001012759.1) - SHH271745 from Creative biogene
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Human CTU2 siRNA - orb278031 from Biorbyt
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CTU2 shRNA Plasmid (Human) - CHJ7530 from Cohesion Biosciences
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CTU2 miRNA 3'UTR clone - MiUTR1H-05786 from Creative biogene
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CTU2 miRNA 3'UTR clone - MiUTR1H-05787 from Creative biogene
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