WDR61

Gene Symbol WDR61
Entrez Gene 80349
Alt Symbol REC14, SKI8
Species Human
Gene Type protein-coding
Description WD repeat domain 61
Other Description SKI8 homolog|WD repeat-containing protein 61|meiotic recombination REC14 protein homolog|recombination protein REC14
Swissprots Q6IA22 Q9GZS3 Q7Z4X4 D3DW84
Accessions EAW99173 EAW99174 EAW99175 Q9GZS3 AF100786 AAP97225 AF127799 AAP97249 AF309553 AAG31639 AK024754 BAB14986 AK025098 AK300838 BAG62489 AK304617 BAG65399 AK310477 AK311320 BC010080 AAH10080 BI916225 BU528743 CR457333 CAG33614 DB451240 HQ447187 ADQ31674 XM_011522094 XP_011520396 XR_931918 NM_001303247 NP_001290176 NM_001303248 NP_001290177 NM_025234 NP_079510
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000305|PubMed:16024656}.
Top Pathways RNA degradation

WDR61 (D-13) - sc-104765 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

WDR61 (WW-5) - sc-100897 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
WDR61 (WW-5): sc-100897. Western blot analysis of WDR61 expression in HeLa whole cell lysate.

WDR61 (T-12) - sc-104767 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-WDR61 antibody - ab57840 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
WDR61 antibody (ab57840) used in immunofluorescence at 10ug/ml on HeLa cells.

Anti-WDR61 antibody - ab103366 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-WDR61 antibody (ab103366) at 5 µg/ml + Mouse brain tissue lysate at 50 µg

Anti-WDR61 Antibody (aa92-305, clone 4C4) - LS-C340333 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4C4
IHC of paraffin-embedded Carcinoma of Human prostate tissue using anti-WDR61 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min).

Anti-WDR61 Antibody (N-Terminus) IHC-plus™ - LS-B12156 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of WDR61 in mouse brain tissue with WDR61 antibody at 5 ug/ml.

Anti-WDR61 Antibody (aa122-149, APC) - LS-C273524 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa122-149, Biotin) - LS-C273525 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa122-149, AP) - LS-C273523 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa122-149, FITC) - LS-C273526 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa122-149, Azide-free, HRP) - LS-C273527 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa122-149, PE) - LS-C273528 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa121-149) - LS-C326343 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-WDR61 Antibody (aa1-146, Azide-free) - LS-C329101 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-WDR61 Antibody (aa122-149) - LS-C157368 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
WDR61 Antibody western blot of A549 cell line lysates (35 ug/lane). The WDR61 antibody detected the WDR61 protein (arrow).

Anti-WDR61 Antibody (N-Terminus) - LS-C201948 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human HeLa. WDR61 antibody dilution 1.0 ug/ml.

Anti-WDR61 Antibody (aa92-305, clone 1D4) - LS-C340335 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 1D4
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WDR61 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-WDR61.

Anti-WDR61 Antibody (aa92-305, clone 4D2) - LS-C340336 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 4D2
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY WDR61 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-WDR61.

Anti-WDR61 Antibody (aa92-305, clone 2H10) - LS-C340334 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 2H10
IHC of paraffin-embedded Human pancreas tissue using anti-WDR61 mouse monoclonal antibody. (Heat-induced epitope retrieval by 1 mM EDTA in 10mM Tris, pH8.5, 120°C for 3min)(1:150).

WDR61 Antibody - NBP1-80845 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: WDR61 Antibody [NBP1-80845] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4. Lane 3: Human cell line U-251MG sp. Lane 4: Human plasma (IgG/HSA depleted). Lane 5: Human liver tissue. Lane 6: Human tonsil tissue

WDR61 Antibody - NBP1-80844 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: WDR61 Antibody [NBP1-80844] - Lane 1: NIH-3T3 cell lysate (Mouse embryonic fibroblast cells). Lane 2: NBT-II cell lysate (Rat Wistar bladder tumor cells).

WDR61 Antibody - NBP2-20896 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

WDR61 Antibody (3E5-1A12) - H00080349-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3E5-1A12
Western Blot: WDR61 Antibody (3E5-1A12) [H00080349-M01] - REC14 monoclonal antibody (M01), clone 3E5-1A12 Analysis of REC14 expression in Hela.

WDR61 Antibody - H00080349-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: WDR61 Antibody [H00080349-B01] - analysis of WDR61 expression in transfected 293T cell line by WDR61 MaxPab polyclonal antibody (B01). Lane 1: WDR61 transfected lysate (33.60 KDa). Lane 2: Non-transfected lysate.
Search more