WDR61

Gene Symbol	WDR61
Entrez Gene	80349
Alt Symbol	REC14, SKI8
Species	Human
Gene Type	protein-coding
Description	WD repeat domain 61
Other Description	SKI8 homolog|WD repeat-containing protein 61|meiotic recombination REC14 protein homolog|recombination protein REC14
Swissprots	Q6IA22 Q9GZS3 Q7Z4X4 D3DW84
Accessions	EAW99173 EAW99174 EAW99175 Q9GZS3 AF100786 AAP97225 AF127799 AAP97249 AF309553 AAG31639 AK024754 BAB14986 AK025098 AK300838 BAG62489 AK304617 BAG65399 AK310477 AK311320 BC010080 AAH10080 BI916225 BU528743 CR457333 CAG33614 DB451240 HQ447187 ADQ31674 XM_011522094 XP_011520396 XR_931918 NM_001303247 NP_001290176 NM_001303248 NP_001290177 NM_025234 NP_079510
Function	Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location	Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000305|PubMed:16024656}.
Top Pathways	RNA degradation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human WDR61 full length protein - ab164269 from Abcam Category Protein Source Wheat germ Species Human

WDR61 Antibody Blocking Peptide - LS-E5761 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WDR61 Protein - H00080349-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

WDR61-Antibody-Center-Blocking-Peptide - BP18296c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

WDR61 - H00080349-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

WDR61 - H00080349-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

WDR61 Peptide - 7985P from ProSci Category Peptide Species Human

WDR61 fusion protein - ag18215 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

WDR61 fusion protein - Ag18443 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human WDR61, GST-tagged - WDR61-3721H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human WD repeat-containing protein 61(WDR61) - CSB-YP872416HU CSB-EP872416HU CSB-BP872416HU CSB-MP872416HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

WDR61 - TP303963 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

WD repeat-containing protein 61(WDR61) , Recombinant Protein - MBS1477606 from MyBioSource Category Protein Prices $1,655.00, $1,655.00, $2,120.00, $2,120.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

WDR61 Recombinant Protein Antigen - NBP1-80845PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WDR61 Recombinant Protein Antigen - NBP1-80844PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

WDR61 Peptide, Human - M34GP17440H from Creative Peptides Category Peptide Source Synthetic. Species Human

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