| Gene Symbol | WDR61 |
|---|---|
| Entrez Gene | 80349 |
| Alt Symbol | REC14, SKI8 |
| Species | Human |
| Gene Type | protein-coding |
| Description | WD repeat domain 61 |
| Other Description | SKI8 homolog|WD repeat-containing protein 61|meiotic recombination REC14 protein homolog|recombination protein REC14 |
| Swissprots | Q6IA22 Q9GZS3 Q7Z4X4 D3DW84 |
| Accessions | EAW99173 EAW99174 EAW99175 Q9GZS3 AF100786 AAP97225 AF127799 AAP97249 AF309553 AAG31639 AK024754 BAB14986 AK025098 AK300838 BAG62489 AK304617 BAG65399 AK310477 AK311320 BC010080 AAH10080 BI916225 BU528743 CR457333 CAG33614 DB451240 HQ447187 ADQ31674 XM_011522094 XP_011520396 XR_931918 NM_001303247 NP_001290176 NM_001303248 NP_001290177 NM_025234 NP_079510 |
| Function | Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000305|PubMed:16024656}. |
| Top Pathways | RNA degradation |