WDR61

Gene Symbol WDR61
Entrez Gene 80349
Alt Symbol REC14, SKI8
Species Human
Gene Type protein-coding
Description WD repeat domain 61
Other Description SKI8 homolog|WD repeat-containing protein 61|meiotic recombination REC14 protein homolog|recombination protein REC14
Swissprots Q6IA22 Q9GZS3 Q7Z4X4 D3DW84
Accessions EAW99173 EAW99174 EAW99175 Q9GZS3 AF100786 AAP97225 AF127799 AAP97249 AF309553 AAG31639 AK024754 BAB14986 AK025098 AK300838 BAG62489 AK304617 BAG65399 AK310477 AK311320 BC010080 AAH10080 BI916225 BU528743 CR457333 CAG33614 DB451240 HQ447187 ADQ31674 XM_011522094 XP_011520396 XR_931918 NM_001303247 NP_001290176 NM_001303248 NP_001290177 NM_025234 NP_079510
Function Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through interaction with POLR2A CTD non- phosphorylated and 'Ser-2'- and 'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1. PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL. PAF1C is involved in histone modifications such as ubiquitination of histone H2B and methylation on histone H3 'Lys-4' (H3K4me3). PAF1C recruits the RNF20/40 E3 ubiquitin-protein ligase complex
Subcellular Location Nucleus {ECO:0000269|PubMed:16024656}. Cytoplasm {ECO:0000305|PubMed:16024656}.
Top Pathways RNA degradation

WDR61 293T Cell Transient Overexpression Lysate(Denatured) - H00080349-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

WDR61 293 Cell Lysate - 405460 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

WDR61 Overexpression Lysate (Denatured) - H00080349-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
WDR61 transfected lysate.

WDR61 Overexpression Lysate (Native) - NBL1-17822 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: WDR61 Overexpression Lysate (Adult Normal) [NBL1-17822] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for WDR61.

WDR61 Over-expression Lysate Product - GWB-5A3A05 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

WDR61 Overexpression Lysate (Denatured) - H00080349-T02 from Novus Biologicals

Category Cell Lysate
Prices $299.00
Sizes 100 µl

Panoply™ Human WDR61 Knockdown Stable Cell Line - CSC-DC017440 from Creative biogene

Category Cell Line
Species Human
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