| Gene Symbol | CDCA8 |
|---|---|
| Entrez Gene | 55143 |
| Alt Symbol | BOR, BOREALIN, DasraB, MESRGP |
| Species | Human |
| Gene Type | protein-coding |
| Description | cell division cycle associated 8 |
| Other Description | Dasra B|borealin|cell division cycle-associated protein 8|dasra-B|hDasra-B|pluripotent embryonic stem cell-related gene 3 protein |
| Swissprots | Q96AM3 D3DPT4 Q9NVW5 Q53HN1 Q53HL2 |
| Accessions | EAX07324 EAX07325 Q53HL2 AK001330 BAA91629 AK022104 BAB13961 AK022606 BAB14125 AK026423 AK222549 BAD96269 AK222568 BAD96288 AK291917 BAF84606 AK302116 BAG63495 AY508815 AAR91699 BC000703 AAH00703 BC001651 AAH01651 BC008079 AAH08079 BC016944 AAH16944 HQ447173 ADQ31660 NM_001256875 NP_001243804 NM_018101 NP_060571 |
| Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
| Subcellular Location | Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. |