Gene Symbol | CDCA8 |
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Entrez Gene | 55143 |
Alt Symbol | BOR, BOREALIN, DasraB, MESRGP |
Species | Human |
Gene Type | protein-coding |
Description | cell division cycle associated 8 |
Other Description | Dasra B|borealin|cell division cycle-associated protein 8|dasra-B|hDasra-B|pluripotent embryonic stem cell-related gene 3 protein |
Swissprots | Q96AM3 D3DPT4 Q9NVW5 Q53HN1 Q53HL2 |
Accessions | EAX07324 EAX07325 Q53HL2 AK001330 BAA91629 AK022104 BAB13961 AK022606 BAB14125 AK026423 AK222549 BAD96269 AK222568 BAD96288 AK291917 BAF84606 AK302116 BAG63495 AY508815 AAR91699 BC000703 AAH00703 BC001651 AAH01651 BC008079 AAH08079 BC016944 AAH16944 HQ447173 ADQ31660 NM_001256875 NP_001243804 NM_018101 NP_060571 |
Function | Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}. |
Subcellular Location | Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells. |
Human Borealin/CDCA8 protein fragment - ab107144 from Abcam
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CDCA8 / Borealin Antibody Blocking Peptide - LS-E1920 from LifeSpan Bioscience
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CDCA8 / Borealin Antibody Blocking Peptide - LS-E3313 from LifeSpan Bioscience
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CDCA8 / Borealin Antibody Blocking Peptide - LS-E30551 from LifeSpan Bioscience
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Borealin Blocking Peptide - NBP1-22832PEP from Novus Biologicals
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Borealin Recombinant Protein - H00055143-P01 from Novus Biologicals
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Bora Blocking Peptide - NBP1-77013PEP from Novus Biologicals
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Bora Blocking Peptide - NBP1-77346PEP from Novus Biologicals
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Borealin Blocking Peptide - NBP1-77330PEP from Novus Biologicals
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Recombinant Human Borealin Protein - NBP1-72298 from Novus Biologicals
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Borealin Peptide - P0419 from Novus Biologicals
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CDCA8-Antibody-N-term-Blocking-peptide - BP12760a from Abgent, a WuXi AppTec company
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CDCA8-Antibody-Center-Blocking-Peptide - BP1447c from Abgent, a WuXi AppTec company
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CDCA8 Protein (OPPA00122) - OPPA00122 from Aviva Systems Biology
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Human CDCA8 protein - orb168087 from Biorbyt
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CDCA8 protein (His tag) - 80R-1807 from Fitzgerald
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CDCA8 - H00055143-P01-02 from Acris Antibodies
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CDCA8 / Borealin (19-280, His-tag) - AR09990PU-L from Acris Antibodies
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CDCA8 / Borealin (19-280, His-tag) - AR09990PU-N from Acris Antibodies
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CDCA8 / Borealin Control Peptide - AP30218CP-N from Acris Antibodies
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Cell Division Cycle Associated 8, Human Recombinant - 228-12976-1 from RayBiotech
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Recombinant Human Cell Division Cycle Associated 8 - 228-12976-2 from RayBiotech
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Recombinant Human Cell Division Cycle Associated 8 - 228-12976-3 from RayBiotech
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CDCA8, 19-280aa, Human, His tag, E.coli - 01-P1050 from ARP American Research Products
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CDCA8 Peptide - 4751P from ProSci
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