CDCA8

Gene Symbol CDCA8
Entrez Gene 55143
Alt Symbol BOR, BOREALIN, DasraB, MESRGP
Species Human
Gene Type protein-coding
Description cell division cycle associated 8
Other Description Dasra B|borealin|cell division cycle-associated protein 8|dasra-B|hDasra-B|pluripotent embryonic stem cell-related gene 3 protein
Swissprots Q96AM3 D3DPT4 Q9NVW5 Q53HN1 Q53HL2
Accessions EAX07324 EAX07325 Q53HL2 AK001330 BAA91629 AK022104 BAB13961 AK022606 BAB14125 AK026423 AK222549 BAD96269 AK222568 BAD96288 AK291917 BAF84606 AK302116 BAG63495 AY508815 AAR91699 BC000703 AAH00703 BC001651 AAH01651 BC008079 AAH08079 BC016944 AAH16944 HQ447173 ADQ31660 NM_001256875 NP_001243804 NM_018101 NP_060571
Function Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment. {ECO:0000269|PubMed:15249581, ECO:0000269|PubMed:15260989, ECO:0000269|PubMed:16571674, ECO:0000269|PubMed:18243099}.
Subcellular Location Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere. Note=Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis. Colocalizes with SENP3 in the nucleolus in interphase cells.

Borealin (A-5) - sc-376635 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Borealin (A-5): sc-376635. Western blot analysis of Borealin expression in HL-60 whole cell lysate (A) and rat kidney tissue extract (B).

Borealin (H-41) - sc-98869 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Borealin (H-41): sc-98869. Western blot analysis of Borealin expression in HL-60 (A), MDA-MB-468 (B) and KNRK (C) nuclear extracts.

Borealin (N-15) - sc-47955 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Borealin (N-15): sc-47955. Western blot analysis of Borealin expression in KNRK nuclear extract.

Borealin (G-25) - sc-130705 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Borealin (G-25): sc-130705. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human lung carcinoma tissue showing cytoplasmic localization.

Anti-Borealin/CDCA8 antibody - ab70910 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-Borealin/CDCA8 antibody (ab70910) at 1/100 dilution + HL60 cell line lysates at 35 µg

Anti-Borealin/CDCA8 antibody - ab74473 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Lane 1 : Anti-Borealin/CDCA8 antibody (ab74473) at 1 µg/mlLane 2 : Anti-Borealin/CDCA8 antibody (ab74473) at 2 µg/mlLane 1 : Rat kidney lysateLane 2 : Rat kidney lysateLysates/proteins at 15 µg per lane.

Anti-Borealin/CDCA8 antibody - ab67126 from Abcam

Prices $380.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-Borealin/CDCA8 antibody (ab67126) at 1/500 dilutionLane 1 : Borealin/CDCA8 transfected 293T cell lysateLane 2 : Untransfected 293T cell lysateSecondaryGoat anti mouse IgG (H&L)-HRP conjugate secondary antibody at 1/2500 dilution

Anti-Borealin/CDCA8 antibody - N-terminal - ab171148 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Borealin/CDCA8 antibody - N-terminal (ab171148) at 1/50 dilutionLane 1 : Non-transfected 293 cell lysateLane 2 : 293 cell lysate transiently transfected with Borealin/CDCA8Lysates/proteins at 2 µg per lane.

Anti-CDCA8 / Borealin Antibody (clone 6A8) - LS-C340344 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 6A8
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDCA8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDCA8 (1:2000).

Anti-CDCA8 / Borealin Antibody - LS-C331056 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of HEX293 cell lysate using CDCA8 antibody.

Anti-CDCA8 / Borealin Antibody (clone 5A6) - LS-C340383 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5A6
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CDCA8 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CDCA8 (1:2000).

Anti-CDCA8 / Borealin Antibody (N-Terminus) - LS-C83903 from LifeSpan Bioscience

Prices $345.00, $1,035.00
Sizes 100 µg, 500 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of CDCA8 in Rat Kidney cells with CDCA8 antibody at 20 ug/ml.

Anti-CDCA8 / Borealin Antibody (aa16-46) - LS-C168603 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
CDCA8 Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human esophageal carcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-CDCA8 / Borealin Antibody (aa200-250, Biotin) - LS-C143117 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCA8 / Borealin Antibody (aa200-250, DY650) - LS-C143118 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCA8 / Borealin Antibody (aa200-250, DY488) - LS-C143119 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCA8 / Borealin Antibody (aa200-250, HRP) - LS-C143120 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCA8 / Borealin Antibody (aa200-250, DY550) - LS-C143121 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-CDCA8 / Borealin Antibody (Internal) - LS-C142726 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Borealin Antibody - Western blot on mouse kidney lysate.

Anti-CDCA8 / Borealin Antibody (clone 181CT41.2.3, AP) - LS-C250190 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 181CT41.2.3

Anti-CDCA8 / Borealin Antibody (clone 181CT41.2.3, APC) - LS-C250191 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 181CT41.2.3

Anti-CDCA8 / Borealin Antibody (clone 181CT41.2.3, Biotin) - LS-C250192 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 181CT41.2.3

Anti-CDCA8 / Borealin Antibody (clone 181CT41.2.3, Azide-free, HRP) - LS-C250195 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 181CT41.2.3

Anti-CDCA8 / Borealin Antibody (clone 181CT41.2.3, FITC) - LS-C250194 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 181CT41.2.3

Anti-CDCA8 / Borealin Antibody - LS-C192227 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CDCA8 pAb in extracts from HEK293 cells.
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