NEK8

Gene Symbol NEK8
Entrez Gene 284086
Alt Symbol JCK, NEK12A, NPHP9, RHPD2
Species Human
Gene Type protein-coding
Description NIMA-related kinase 8
Other Description NIMA (never in mitosis gene a)- related kinase 8|NIMA-family kinase NEK8|NIMA-related kinase 12a|nephrocystin 9|never in mitosis A-related kinase 8|nimA-related protein kinase 8|nima-related protein kinase 12a|serine/threonine-protein kinase Nek8|serine/thrionine-protein kinase NEK8
Swissprots Q8NDH1 Q14CL7 A6NIC5 Q86SG6 Q2M1S6
Accessions EAW51135 EAW51136 EAW51137 Q86SG6 AK301429 BAG62957 AL833909 CAD38765 AY242354 AAO88243 AY267371 AAP04006 BC112240 AAI12241 BC113705 AAI13706 HQ258347 ADR83101 XM_011524638 XP_011522940 XM_011524639 XP_011522941 XM_011524640 XP_011522942 XM_011524641 XP_011522943 XM_011524642 XP_011522944 XM_011524643 XP_011522945 XM_011524644 XP_011522946 XM_011524645 XP_011522947 XR_934448 NM_178170 NP_835464
Function Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000250, ECO:0000269|PubMed:23418306}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton. Cell projection, cilium {ECO:0000250}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
Tissue Specificity Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. {ECO:0000269|PubMed:15019993}.

Nek8 (L-20) - sc-50760 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Nek8 (C-20) - sc-50758 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Nek8 (H-142) - sc-367140 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Nek8 (K-24) - sc-130826 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Rabbit
Clonality Polyclonal
Nek8 (K-24): sc-130826. Western blot analysis of Nek8 expression in A2058 whole cell lysate.

Nek8 (N-17) - sc-50761 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NEK8 antibody - ab175320 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence analysis of HeLa cells using ab175320. Blue DAPI for nuclear staining.

Anti-NEK8 antibody - ab116721 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-NEK8 antibody (ab116721) at 1/100 dilution + A2058 cell line lysate at 35 µg

Anti-NEK8 antibody - ab169406 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-NEK8 antibody (ab169406) at 1 µg/mlLane 1 : NEK8 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.

Anti-NEK8 antibody - Aminoterminal end - ab38005 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NEK8 antibody - Aminoterminal end (ab38005) at 1/100 dilution + A2058 cell lysate

Anti-NEK8 antibody - Carboxyterminal end - ab38004 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-NEK8 antibody - Carboxyterminal end (ab38004) at 1/100 dilution + A2058 cell lysate

Anti-NEK8 Antibody (aa573-604) - LS-C98057 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-NEK8 antibody is used in Western blot to detect NEK8 in A2058 cell lysate.

Anti-NEK8 Antibody (aa519-547, AP) - LS-C237963 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (aa65-95) - LS-C98056 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
The anti-NEK8 antibody is used in Western blot to detect NEK8 in A2058 cell lysate.

Anti-NEK8 Antibody (aa519-547, Biotin) - LS-C237964 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (aa519-547, APC) - LS-C237965 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (aa519-547, FITC) - LS-C237966 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (aa519-547, PE) - LS-C237967 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (C-Terminus, APC) - LS-C245121 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (C-Terminus, AP) - LS-C245120 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (C-Terminus, FITC) - LS-C245123 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (C-Terminus, Biotin) - LS-C245122 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (C-Terminus, PE) - LS-C245124 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody (N-Terminus, AP) - LS-C245125 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-NEK8 Antibody - LS-C192308 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of NEK8 pAb in extracts from 293T, MCF7, Hela, Jurkat, V251, A549, K562 cells and mouse liver,testis tissues.

Anti-NEK8 Antibody (N-Terminus, APC) - LS-C245126 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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