NEK8

Gene Symbol NEK8
Entrez Gene 284086
Alt Symbol JCK, NEK12A, NPHP9, RHPD2
Species Human
Gene Type protein-coding
Description NIMA-related kinase 8
Other Description NIMA (never in mitosis gene a)- related kinase 8|NIMA-family kinase NEK8|NIMA-related kinase 12a|nephrocystin 9|never in mitosis A-related kinase 8|nimA-related protein kinase 8|nima-related protein kinase 12a|serine/threonine-protein kinase Nek8|serine/thrionine-protein kinase NEK8
Swissprots Q8NDH1 Q14CL7 A6NIC5 Q86SG6 Q2M1S6
Accessions EAW51135 EAW51136 EAW51137 Q86SG6 AK301429 BAG62957 AL833909 CAD38765 AY242354 AAO88243 AY267371 AAP04006 BC112240 AAI12241 BC113705 AAI13706 HQ258347 ADR83101 XM_011524638 XP_011522940 XM_011524639 XP_011522941 XM_011524640 XP_011522942 XM_011524641 XP_011522943 XM_011524642 XP_011522944 XM_011524643 XP_011522945 XM_011524644 XP_011522946 XM_011524645 XP_011522947 XR_934448 NM_178170 NP_835464
Function Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000250, ECO:0000269|PubMed:23418306}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton. Cell projection, cilium {ECO:0000250}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
Tissue Specificity Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. {ECO:0000269|PubMed:15019993}.

Nek8 CRISPR/Cas9 KO Plasmid (h) - sc-406984 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 HDR Plasmid (h) - sc-406984-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 Double Nickase Plasmid (h) - sc-406984-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 Double Nickase Plasmid (h2) - sc-406984-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 CRISPR Activation Plasmid (h) - sc-406984-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 CRISPR Activation Plasmid (h2) - sc-406984-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 Lentiviral Activation Particles (h) - sc-406984-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 Lentiviral Activation Particles (h2) - sc-406984-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nek8 siRNA (h) - sc-61176 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nek8 shRNA Plasmid (h) - sc-61176-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nek8 shRNA (h) Lentiviral Particles - sc-61176-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEK8 RNAi - H00284086-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU154071 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

MISSION® siRNA - SIHK1412 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1411 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK1413 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2564 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2564 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06867 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr06867

NEK8 siRNA (Human) - CRJ6968 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human NEK8 (NM_178170.2) - SHH351296 from Creative biogene

Category siRNA
Species Reactivities Human

Human NEK8 siRNA - orb277469 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NEK8 shRNA Plasmid (Human) - CHJ6968 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NEK8 miRNA 3'UTR clone - MiUTR1H-06721 from Creative biogene

Species Reactivities Human
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