| Gene Symbol |
NEK8
|
| Entrez Gene |
284086
|
| Alt Symbol |
JCK, NEK12A, NPHP9, RHPD2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
NIMA-related kinase 8
|
| Other Description |
NIMA (never in mitosis gene a)- related kinase 8|NIMA-family kinase NEK8|NIMA-related kinase 12a|nephrocystin 9|never in mitosis A-related kinase 8|nimA-related protein kinase 8|nima-related protein kinase 12a|serine/threonine-protein kinase Nek8|serine/thrionine-protein kinase NEK8
|
| Swissprots |
Q8NDH1 Q14CL7 A6NIC5 Q86SG6 Q2M1S6
|
| Accessions |
EAW51135 EAW51136 EAW51137 Q86SG6 AK301429 BAG62957 AL833909 CAD38765 AY242354 AAO88243 AY267371 AAP04006 BC112240 AAI12241 BC113705 AAI13706 HQ258347 ADR83101 XM_011524638 XP_011522940 XM_011524639 XP_011522941 XM_011524640 XP_011522942 XM_011524641 XP_011522943 XM_011524642 XP_011522944 XM_011524643 XP_011522945 XM_011524644 XP_011522946 XM_011524645 XP_011522947 XR_934448 NM_178170 NP_835464
|
| Function |
Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia (By similarity). Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway. {ECO:0000250, ECO:0000269|PubMed:23418306}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton. Cell projection, cilium {ECO:0000250}. Note=Predominantly cytoplasmic. Localizes to the proximal region of the primary cilium and is not observed in dividing cells.
|
| Tissue Specificity |
Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma. {ECO:0000269|PubMed:15019993}.
|
