| Gene Symbol |
RRM2B
|
| Entrez Gene |
50484
|
| Alt Symbol |
MTDPS8A, MTDPS8B, P53R2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ribonucleotide reductase M2 B (TP53 inducible)
|
| Other Description |
TP53-inducible ribonucleotide reductase M2 B|p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 short form beta|p53-inducible ribonucleotide reductase small subunit 2-like protein|ribonucleoside-diphosphate reductase subunit M2 B
|
| Swissprots |
Q86YE3 B4E2N4 Q75PQ6 Q17R22 Q75PY9 Q9NUW3 Q75PQ7 Q9NTD8 Q9NPD6 Q75PY8 Q7LG56
|
| Accessions |
AAY29059 BAA92493 EAW91840 EAW91841 EAW91842 Q7LG56 AB036063 BAA92434 AB163437 BAD11774 AB163438 BAD11775 AB166669 BAD12265 AB166670 BAD12266 AB166671 BAD12267 AK001965 BAA92005 AK023605 AK304354 BAG65196 AL137348 CAB70703 BC042468 AAH42468 BC042948 BC108261 AAI08262 BC117496 AAI17497 BC130628 AAI30629 BX509409 CR627376 CAH10473 DC308409 EU831630 ACE87230 EU831715 ACE86549 HQ258190 ADR82944 NM_001172477 NP_001165948 NM_001172478 NP_001165949 NM_015713 NP_056528
|
| Function |
Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
|
| Tissue Specificity |
Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. {ECO:0000269|PubMed:14583450}.
|
| Top Pathways |
p53 signaling pathway, Purine metabolism, Glutathione metabolism, Pyrimidine metabolism
|