RRM2B

Gene Symbol RRM2B
Entrez Gene 50484
Alt Symbol MTDPS8A, MTDPS8B, P53R2
Species Human
Gene Type protein-coding
Description ribonucleotide reductase M2 B (TP53 inducible)
Other Description TP53-inducible ribonucleotide reductase M2 B|p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 short form beta|p53-inducible ribonucleotide reductase small subunit 2-like protein|ribonucleoside-diphosphate reductase subunit M2 B
Swissprots Q86YE3 B4E2N4 Q75PQ6 Q17R22 Q75PY9 Q9NUW3 Q75PQ7 Q9NTD8 Q9NPD6 Q75PY8 Q7LG56
Accessions AAY29059 BAA92493 EAW91840 EAW91841 EAW91842 Q7LG56 AB036063 BAA92434 AB163437 BAD11774 AB163438 BAD11775 AB166669 BAD12265 AB166670 BAD12266 AB166671 BAD12267 AK001965 BAA92005 AK023605 AK304354 BAG65196 AL137348 CAB70703 BC042468 AAH42468 BC042948 BC108261 AAI08262 BC117496 AAI17497 BC130628 AAI30629 BX509409 CR627376 CAH10473 DC308409 EU831630 ACE87230 EU831715 ACE86549 HQ258190 ADR82944 NM_001172477 NP_001165948 NM_001172478 NP_001165949 NM_015713 NP_056528
Function Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}.
Subcellular Location Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
Tissue Specificity Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. {ECO:0000269|PubMed:14583450}.
Top Pathways p53 signaling pathway, Purine metabolism, Glutathione metabolism, Pyrimidine metabolism

p53R2 CRISPR/Cas9 KO Plasmid (h) - sc-402192 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 HDR Plasmid (h) - sc-402192-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 Double Nickase Plasmid (h) - sc-402192-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 Double Nickase Plasmid (h2) - sc-402192-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 CRISPR Activation Plasmid (h) - sc-402192-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 CRISPR Activation Plasmid (h2) - sc-402192-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 Lentiviral Activation Particles (h) - sc-402192-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 Lentiviral Activation Particles (h2) - sc-402192-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

p53R2 siRNA (h) - sc-36158 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p53R2 shRNA Plasmid (h) - sc-36158-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p53R2 shRNA (h) Lentiviral Particles - sc-36158-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

p53R2 RNAi - H00050484-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU142661 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18687 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18687 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RRM2B siRNA (Human) - CRH9370 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RRM2B - MBS8215446 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RRM2B (NM_015713.4) - SHH399976 from Creative biogene

Category siRNA
Species Reactivities Human

Human RRM2B siRNA - orb269872 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RRM2B shRNA Plasmid (Human) - CHH9370 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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