RRM2B

Gene Symbol	RRM2B
Entrez Gene	50484
Alt Symbol	MTDPS8A, MTDPS8B, P53R2
Species	Human
Gene Type	protein-coding
Description	ribonucleotide reductase M2 B (TP53 inducible)
Other Description	TP53-inducible ribonucleotide reductase M2 B|p53-inducible ribonucleotide reductase small subunit 2 homolog|p53-inducible ribonucleotide reductase small subunit 2 short form beta|p53-inducible ribonucleotide reductase small subunit 2-like protein|ribonucleoside-diphosphate reductase subunit M2 B
Swissprots	Q86YE3 B4E2N4 Q75PQ6 Q17R22 Q75PY9 Q9NUW3 Q75PQ7 Q9NTD8 Q9NPD6 Q75PY8 Q7LG56
Accessions	AAY29059 BAA92493 EAW91840 EAW91841 EAW91842 Q7LG56 AB036063 BAA92434 AB163437 BAD11774 AB163438 BAD11775 AB166669 BAD12265 AB166670 BAD12266 AB166671 BAD12267 AK001965 BAA92005 AK023605 AK304354 BAG65196 AL137348 CAB70703 BC042468 AAH42468 BC042948 BC108261 AAI08262 BC117496 AAI17497 BC130628 AAI30629 BX509409 CR627376 CAH10473 DC308409 EU831630 ACE87230 EU831715 ACE86549 HQ258190 ADR82944 NM_001172477 NP_001165948 NM_001172478 NP_001165949 NM_015713 NP_056528
Function	Plays a pivotal role in cell survival by repairing damaged DNA in a p53/TP53-dependent manner. Supplies deoxyribonucleotides for DNA repair in cells arrested at G1 or G2. Contains an iron-tyrosyl free radical center required for catalysis. Forms an active ribonucleotide reductase (RNR) complex with RRM1 which is expressed both in resting and proliferating cells in response to DNA damage. {ECO:0000269|PubMed:10716435, ECO:0000269|PubMed:11517226, ECO:0000269|PubMed:11719458}.
Subcellular Location	Cytoplasm. Nucleus. Note=Translocates from cytoplasm to nucleus in response to DNA damage.
Tissue Specificity	Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. {ECO:0000269|PubMed:14583450}.
Top Pathways	p53 signaling pathway, Purine metabolism, Glutathione metabolism, Pyrimidine metabolism

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human p53R2 peptide - ab64593 from Abcam Category Peptide

Human p53R2 protein fragment - ab153320 from Abcam Category Protein Source Wheat germ Species Human

p53R2 peptide - ab6237 from Abcam Category Peptide

RRM2B Antibody Blocking Peptide - LS-E4686 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RRM2B Antibody Blocking Peptide - LS-E29954 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

Recombinant Human p53R2 Protein - H00050484-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

p53R2 Blocking Peptide - NBP1-76781PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

RRM2B-Antibody-Center-Blocking-Peptide - BP17054c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

p53R2 peptide - GTX26237 from GeneTex Category Peptide Prices $179.00 Sizes 50 μg Species Human

Human RRM2B protein (His Tag) - orb139603 from Biorbyt Category Protein Prices $527.00, $731.00 Sizes 50 μg, 100 μg Source E. coli Species Human

RRM2B / P53R2 - H00050484-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RRM2B / P53R2 - H00050484-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RRM2B / P53R2 Control Peptide - AP30640CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

p53R2 Peptide - 2383P from ProSci Category Peptide Species Human

RRM2B,p53R2 fusion protein - Ag12499 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

RRM2B,p53R2 fusion protein - ag12483 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human RRM2B, His tagged - RRM2B-2550H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human RRM2B, GST-tagged - RRM2B-2446H from Creative Biomart Category Protein Source E.coli Species Human

Human RRM2B / P53R2 Protein (His Tag) - 13150-H07E-50 from Sino Biological Category Protein Prices $248.00, $398.00 Sizes 50 µg, 100 µg Source E. coli Species Human

p53R2 (F156) Peptide - BS9220P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Ribonucleoside-diphosphate reductase subunit M2 B(RRM2B) - CSB-YP745339HU CSB-EP745339HU CSB-BP745339HU CSB-MP745339HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RRM2B Blocking Peptide - abx161723 from Abbexa Category Peptide Species Human, Mouse, Rat, Monkey

RRM2B Protein - abx163665 from Abbexa Category Protein Species Human, Mouse, Rat

RRM2B / P53R2 - TP310340 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

Recombinant Human RRM2B / P53R2 Protein (His tag) - PKSH030709 from Elabscience Category Protein Source E. coli Species Human

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