| Gene Symbol |
SLC43A1
|
| Entrez Gene |
8501
|
| Alt Symbol |
LAT3, PB39, POV1, R00504
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 43 (amino acid system L transporter), member 1
|
| Other Description |
L-type amino acid transporter 3|large neutral amino acids transporter small subunit 3|prostate cancer overexpressed gene 1 protein|solute carrier family 43, member 1
|
| Swissprots |
O75387
|
| Accessions |
EAW73749 EAW73750 EAW73751 EAW73752 O75387 AA040589 AB103033 BAD00152 AF045584 AAC33004 AK027732 BAG51373 BC001639 AAH01639 BM147085 BQ029981 XM_005274358 XP_005274415 XM_011545320 XP_011543622 XM_011545321 XP_011543623 XM_011545322 XP_011543624 XM_011545323 XP_011543625 XR_950084 NM_001198810 NP_001185739 NM_003627 NP_003618
|
| Function |
Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. {ECO:0000269|PubMed:11956097, ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:9255310, ECO:0000269|PubMed:9722952}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. {ECO:0000269|PubMed:11956097, ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:9255310, ECO:0000269|PubMed:9722952}.
|