Gene Symbol | SLC43A1 |
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Entrez Gene | 8501 |
Alt Symbol | LAT3, PB39, POV1, R00504 |
Species | Human |
Gene Type | protein-coding |
Description | solute carrier family 43 (amino acid system L transporter), member 1 |
Other Description | L-type amino acid transporter 3|large neutral amino acids transporter small subunit 3|prostate cancer overexpressed gene 1 protein|solute carrier family 43, member 1 |
Swissprots | O75387 |
Accessions | EAW73749 EAW73750 EAW73751 EAW73752 O75387 AA040589 AB103033 BAD00152 AF045584 AAC33004 AK027732 BAG51373 BC001639 AAH01639 BM147085 BQ029981 XM_005274358 XP_005274415 XM_011545320 XP_011543622 XM_011545321 XP_011543623 XM_011545322 XP_011543624 XM_011545323 XP_011543625 XR_950084 NM_001198810 NP_001185739 NM_003627 NP_003618 |
Function | Sodium-independent, high affinity transport of large neutral amino acids. Has narrower substrate selectivity compared to SLC7A5 and SLC7A8 and mainly transports branched-chain amino acids and phenylalanine. Plays a role in the development of human prostate cancer, from prostatic intraepithelial neoplasia to invasive prostate cancer. {ECO:0000269|PubMed:11956097, ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:9255310, ECO:0000269|PubMed:9722952}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | In adults, found in all tissues examined with highest expression in pancreas. In fetus, highest expression in liver and lower levels in kidney, and lung. High levels found in prostate cancer cells. {ECO:0000269|PubMed:11956097, ECO:0000269|PubMed:12930836, ECO:0000269|PubMed:9255310, ECO:0000269|PubMed:9722952}. |
SLC43A1 CRISPR/Cas9 KO Plasmid (h) - sc-417236 from Santa Cruz Biotechnology
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SLC43A1 HDR Plasmid (h) - sc-417236-HDR from Santa Cruz Biotechnology
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SLC43A1 Double Nickase Plasmid (h) - sc-417236-NIC from Santa Cruz Biotechnology
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SLC43A1 Double Nickase Plasmid (h2) - sc-417236-NIC-2 from Santa Cruz Biotechnology
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SLC43A1 CRISPR Activation Plasmid (h) - sc-417236-ACT from Santa Cruz Biotechnology
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SLC43A1 CRISPR Activation Plasmid (h2) - sc-417236-ACT-2 from Santa Cruz Biotechnology
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SLC43A1 Lentiviral Activation Particles (h) - sc-417236-LAC from Santa Cruz Biotechnology
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SLC43A1 Lentiviral Activation Particles (h2) - sc-417236-LAC-2 from Santa Cruz Biotechnology
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SLC43A1 siRNA (h) - sc-96581 from Santa Cruz Biotechnology
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SLC43A1 shRNA Plasmid (h) - sc-96581-SH from Santa Cruz Biotechnology
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SLC43A1 shRNA (h) Lentiviral Particles - sc-96581-V from Santa Cruz Biotechnology
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LAT3 RNAi - H00008501-R01 from Novus Biologicals
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MISSION® esiRNA - EHU056951 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN19634 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19634 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR05394 from Sigma-Aldrich
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SLC43A1 siRNA (Human) - CRH5575 from Cohesion Biosciences
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SLC43A1 - MBS8226944 from MyBioSource
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shRNA set against Human SLC43A1 (NM_003627.5) - SHH411288 from Creative biogene
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Human SLC43A1 siRNA - orb266077 from Biorbyt
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SLC43A1 shRNA Plasmid (Human) - CHH5575 from Cohesion Biosciences
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SLC43A1 miRNA 3'UTR clone - MiUTR3H-06225 from Creative biogene
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