Gene Symbol | F11 |
---|---|
Entrez Gene | 2160 |
Alt Symbol | FXI |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor XI |
Other Description | PTA|plasma thromboplastin antecedent |
Swissprots | P03951 Q9Y495 D3DP64 Q4W5C2 |
Accessions | AAA51985 AAN85554 AAY40901 BAA20295 EAX04619 EAX04620 EAX04621 P03951 AF045649 AAC24506 AK313195 BC020617 BC029374 BC119014 AAI19015 BC122863 AAI22864 DA630863 M13142 AAA52487 XM_005262821 XP_005262878 XM_005262822 XP_005262879 XM_005262823 XP_005262880 XM_005262824 XP_005262881 XM_006714137 XP_006714200 XR_938706 XR_938707 NM_000128 NP_000119 NM_019559 |
Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
Subcellular Location | Secreted. |
Tissue Specificity | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
Top Pathways | Complement and coagulation cascades |