Gene Symbol | F11 |
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Entrez Gene | 2160 |
Alt Symbol | FXI |
Species | Human |
Gene Type | protein-coding |
Description | coagulation factor XI |
Other Description | PTA|plasma thromboplastin antecedent |
Swissprots | P03951 Q9Y495 D3DP64 Q4W5C2 |
Accessions | AAA51985 AAN85554 AAY40901 BAA20295 EAX04619 EAX04620 EAX04621 P03951 AF045649 AAC24506 AK313195 BC020617 BC029374 BC119014 AAI19015 BC122863 AAI22864 DA630863 M13142 AAA52487 XM_005262821 XP_005262878 XM_005262822 XP_005262879 XM_005262823 XP_005262880 XM_005262824 XP_005262881 XM_006714137 XP_006714200 XR_938706 XR_938707 NM_000128 NP_000119 NM_019559 |
Function | Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX. |
Subcellular Location | Secreted. |
Tissue Specificity | Isoform 2 is produced by platelets and megakaryocytes but absent from other blood cells. |
Top Pathways | Complement and coagulation cascades |
Factor XI CRISPR/Cas9 KO Plasmid (h) - sc-405706 from Santa Cruz Biotechnology
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Factor XI HDR Plasmid (h) - sc-405706-HDR from Santa Cruz Biotechnology
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Factor XI Double Nickase Plasmid (h) - sc-405706-NIC from Santa Cruz Biotechnology
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Factor XI Double Nickase Plasmid (h2) - sc-405706-NIC-2 from Santa Cruz Biotechnology
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Factor XI CRISPR Activation Plasmid (h) - sc-405706-ACT from Santa Cruz Biotechnology
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Factor XI CRISPR Activation Plasmid (h2) - sc-405706-ACT-2 from Santa Cruz Biotechnology
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Factor XI Lentiviral Activation Particles (h) - sc-405706-LAC from Santa Cruz Biotechnology
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Factor XI Lentiviral Activation Particles (h2) - sc-405706-LAC-2 from Santa Cruz Biotechnology
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Factor XI siRNA (h) - sc-60625 from Santa Cruz Biotechnology
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Factor XI shRNA Plasmid (h) - sc-60625-SH from Santa Cruz Biotechnology
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Factor XI shRNA (h) Lentiviral Particles - sc-60625-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU092081 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1630 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1630 from Sigma-Aldrich
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F11 siRNA (Human) - CRH1502 from Cohesion Biosciences
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Coagulation Factor XI RNAi - H00002160-R01 from Novus Biologicals
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F11 - MBS8205353 from MyBioSource
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shRNA set against Human F11 (NM_000128.3) - SHH288373 from Creative biogene
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shRNA set against Human F11(NM_000128.3) - SHH043147 from Creative biogene
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F11 shRNA Plasmid (Human) - CHH1502 from Cohesion Biosciences
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F11 miRNA 3'UTR clone - MiUTR3H-02481 from Creative biogene
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