| Gene Symbol |
NANOS1
|
| Entrez Gene |
340719
|
| Alt Symbol |
NOS1, SPGF12
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nanos homolog 1 (Drosophila)
|
| Other Description |
EC_Rep1a|NOS-1|nanos homolog 1
|
| Swissprots |
Q8WY41
|
| Accessions |
EAW49409 Q8WY41 AF086393 AF275269 AAL36982 AF458985 AAQ04765 AI276145 BC156179 AAI56180 NM_001009553 NM_199461 NP_955631
|
| Function |
May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.
|
| Subcellular Location |
Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
|
| Tissue Specificity |
Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21421998}.
|