NANOS1

Gene Symbol	NANOS1
Entrez Gene	340719
Alt Symbol	NOS1, SPGF12
Species	Human
Gene Type	protein-coding
Description	nanos homolog 1 (Drosophila)
Other Description	EC_Rep1a|NOS-1|nanos homolog 1
Swissprots	Q8WY41
Accessions	EAW49409 Q8WY41 AF086393 AF275269 AAL36982 AF458985 AAQ04765 AI276145 BC156179 AAI56180 NM_001009553 NM_199461 NP_955631
Function	May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}.
Subcellular Location	Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells.
Tissue Specificity	Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21421998}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Nanos Homologue 1 (NANOS1) peptide - ab15742 from Abcam Category Peptide

Nanos Homologue 1 (NANOS1) peptide (281-292) - ab45711 from Abcam Category Peptide Species Human

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E2953 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E3251 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E25846 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E30529 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E30530 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E15147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NANOS1 / NOS1 Antibody Blocking Peptide - LS-E15146 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOS1 / nNOS Antibody Blocking Peptide - LS-E25277 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NOS1 / nNOS Antibody Blocking Peptide - LS-E7456 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human nNOS Protein - H00004842-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

NANOS1 Blocking Peptide - NBP1-77327PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NANOS1 Blocking Peptide - NBP1-76366PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

NANOS1 Peptide - P0368 from Novus Biologicals Category Peptide Species Human

Nanos-Homologue-1-NANOS1-Antibody-C-term-Blocking-peptide - BP1407b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NANOS1-Antibody-Center-Blocking-Peptide - BP14401c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

NANOS1 blocking peptide - GTX89524-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

NANOS1 Blocking Peptide - 33R-7798 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NANOS1 Blocking Peptide - 33R-1875 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Nanos Homologue 1 Peptide - AC21-0678-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NANOS1 Control Peptide - AP30579CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

NANOS1 Control Peptide - AP30580CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Nanos1 Peptide - 4683P from ProSci Category Peptide Species Human

Nanos1 Peptide - 4685P from ProSci Category Peptide Species Human

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