NANOS1
| Gene Symbol | NANOS1 |
|---|---|
| Entrez Gene | 340719 |
| Alt Symbol | NOS1, SPGF12 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nanos homolog 1 (Drosophila) |
| Other Description | EC_Rep1a|NOS-1|nanos homolog 1 |
| Swissprots | Q8WY41 |
| Accessions | EAW49409 Q8WY41 AF086393 AF275269 AAL36982 AF458985 AAQ04765 AI276145 BC156179 AAI56180 NM_001009553 NM_199461 NP_955631 |
| Function | May act as a translational repressor which regulates translation of specific mRNAs by forming a complex with PUM2 that associates with the 3'-UTR of mRNA targets. Capable of interfering with the proadhesive and anti-invasive functions of E-cadherin. Up-regulates the production of MMP14 to promote tumor cell invasion. {ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680}. |
| Subcellular Location | Cytoplasm, perinuclear region. Cytoplasm. Note=Colocalizes with SNAPIN and PUM2 in the perinuclear region of germ cells. |
| Tissue Specificity | Testis and ovary (at protein level). Predominantly expressed in testis. Specifically expressed during germline development. In adult tissues, it is mainly expressed in spermatogonia, the stem cells of the germline. Also expressed during meiosis in spermatocytes. Not present in late, post-meiotic stage germ cells. Expressed in fetal ovaries, while it is weakly or not expressed in mature postmeiotic oocytes, suggesting that it may be expressed in premeiotic female germ cells. Expressed at high levels only in the E-cadherin deficient cell lines. Highly expressed in lung carcinomas and mostly detected in invasive tumor cells and its expression correlates with tumor aggressiveness. {ECO:0000269|PubMed:12690449, ECO:0000269|PubMed:17047063, ECO:0000269|PubMed:18223680, ECO:0000269|PubMed:19168546, ECO:0000269|PubMed:21421998}. |
Nanos1 CRISPR/Cas9 KO Plasmid (h) - sc-404414 from Santa Cruz Biotechnology
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Nanos1 HDR Plasmid (h) - sc-404414-HDR from Santa Cruz Biotechnology
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Nanos1 Double Nickase Plasmid (h) - sc-404414-NIC from Santa Cruz Biotechnology
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Nanos1 Double Nickase Plasmid (h2) - sc-404414-NIC-2 from Santa Cruz Biotechnology
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Nanos1 CRISPR Activation Plasmid (h) - sc-404414-ACT from Santa Cruz Biotechnology
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Nanos1 CRISPR Activation Plasmid (h2) - sc-404414-ACT-2 from Santa Cruz Biotechnology
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Nanos1 Lentiviral Activation Particles (h) - sc-404414-LAC from Santa Cruz Biotechnology
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Nanos1 Lentiviral Activation Particles (h2) - sc-404414-LAC-2 from Santa Cruz Biotechnology
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Nanos1 siRNA (h) - sc-75864 from Santa Cruz Biotechnology
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Nanos1 shRNA Plasmid (h) - sc-75864-SH from Santa Cruz Biotechnology
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Nanos1 shRNA (h) Lentiviral Particles - sc-75864-V from Santa Cruz Biotechnology
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nNOS RNAi - H00004842-R01 from Novus Biologicals
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NANOS1 RNAi - H00340719-R02 from Novus Biologicals
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NANOS1 RNAi - H00340719-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN14940 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14940 from Sigma-Aldrich
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NANOS1 siRNA (Human) - CRJ7363 from Cohesion Biosciences
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shRNA set against Human Nanos1 (NM_199461.2) - SHH349168 from Creative biogene
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shRNA set against Human NANOS1(NM_199461.2) - SHH215345 from Creative biogene
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Human NANOS1 siRNA - orb277864 from Biorbyt
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NANOS1 shRNA Plasmid (Human) - CHJ7363 from Cohesion Biosciences
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NANOS1 miRNA 3'UTR clone - MiUTR1H-06629 from Creative biogene
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