Gene Symbol |
MECR
|
Entrez Gene |
51102
|
Alt Symbol |
CGI-63, FASN2B, NRBF1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
mitochondrial trans-2-enoyl-CoA reductase
|
Other Description |
homolog of yeast 2-enoyl thioester reductase|mitochondrial 2-enoyl thioester reductase|nuclear receptor binding factor 1|trans-2-enoyl-CoA reductase, mitochondrial
|
Swissprots |
Q5SYU2 Q9BV79 Q5SYU1 Q9Y373 Q6IBU9 Q5SYU0 B3KT72
|
Accessions |
EAX07653 EAX07654 EAX07655 EAX07656 Q9BV79 AF151821 AAD34058 AK025830 AK095099 BAG52984 AK225687 AK226084 AK300889 BAG62530 AK315274 AL711403 BC001419 AAH01419 CR456703 CAG32984 H17678 HY116509 JF432515 ADZ15732 XM_005245885 XP_005245942 XM_005245887 XP_005245944 XM_011541539 XP_011539841 XM_011541540 XP_011539842 XM_011541541 XP_011539843 XM_011541542 XP_011539844 XM_011541543 XP_011539845 XM_011541544 XP_011539846 XM_011541545 XP_011539847 XM_011541546 XP_011539848 XM_011541547 XP_011539849 XM_011541548 XP_011539850 XM_011541549 XP_011539851 XM_011541550 XP_011539852 XM_011541551 XP_011539853 XM_011541552 XP_011539854 XM_011541553 XP_011539855 XM_011541554 XP_011539856 XR_946662 XR_946663 XR_946664 NM_001024732 NP_001019903 NM_016011 NP_057095
|
Function |
Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis. {ECO:0000269|PubMed:18479707}.
|
Subcellular Location |
Isoform 1: Mitochondrion {ECO:0000269|PubMed:12654921}.
|
Tissue Specificity |
Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung. {ECO:0000269|PubMed:12654921}.
|
Top Pathways |
Fatty acid elongation, Fatty acid metabolism
|