| Gene Symbol |
RRAD
|
| Entrez Gene |
6236
|
| Alt Symbol |
RAD, RAD1, REM3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras-related associated with diabetes
|
| Other Description |
GTP-binding protein RAD|RAS (RAD and GEM) like GTP binding 3|ras associated with diabetes
|
| Swissprots |
Q96F39 P55042
|
| Accessions |
AAB17064 EAW83053 EAW83054 EAW83055 P55042 AK290613 BAF83302 BC011645 AAH11645 BC057815 AAH57815 BP257026 DQ891951 ABM82877 DQ895137 ABM86063 L24564 AAA36540 N93445 NM_001128850 NP_001122322 NM_004165 NP_004156
|
| Function |
May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. {ECO:0000250, ECO:0000269|PubMed:18056528}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}.
|
| Tissue Specificity |
Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. {ECO:0000269|PubMed:18056528}.
|
![Western Blot: RRAD Overexpression Lysate (Adult Normal) [NBP2-09486] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RRAD.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3131_RRAD%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-09486-img0001.jpg)