Gene Symbol | RRAD |
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Entrez Gene | 6236 |
Alt Symbol | RAD, RAD1, REM3 |
Species | Human |
Gene Type | protein-coding |
Description | Ras-related associated with diabetes |
Other Description | GTP-binding protein RAD|RAS (RAD and GEM) like GTP binding 3|ras associated with diabetes |
Swissprots | Q96F39 P55042 |
Accessions | AAB17064 EAW83053 EAW83054 EAW83055 P55042 AK290613 BAF83302 BC011645 AAH11645 BC057815 AAH57815 BP257026 DQ891951 ABM82877 DQ895137 ABM86063 L24564 AAA36540 N93445 NM_001128850 NP_001122322 NM_004165 NP_004156 |
Function | May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. {ECO:0000250, ECO:0000269|PubMed:18056528}. |
Subcellular Location | Cell membrane {ECO:0000250}. |
Tissue Specificity | Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. {ECO:0000269|PubMed:18056528}. |
Rad GTPase CRISPR/Cas9 KO Plasmid (h) - sc-409678 from Santa Cruz Biotechnology
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Rad GTPase HDR Plasmid (h) - sc-409678-HDR from Santa Cruz Biotechnology
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Rad GTPase Double Nickase Plasmid (h) - sc-409678-NIC from Santa Cruz Biotechnology
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Rad GTPase Double Nickase Plasmid (h2) - sc-409678-NIC-2 from Santa Cruz Biotechnology
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Rad GTPase CRISPR Activation Plasmid (h) - sc-409678-ACT from Santa Cruz Biotechnology
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Rad GTPase CRISPR Activation Plasmid (h2) - sc-409678-ACT-2 from Santa Cruz Biotechnology
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Rad GTPase Lentiviral Activation Particles (h) - sc-409678-LAC from Santa Cruz Biotechnology
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Rad GTPase Lentiviral Activation Particles (h2) - sc-409678-LAC-2 from Santa Cruz Biotechnology
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Rad GTPase siRNA (h) - sc-61433 from Santa Cruz Biotechnology
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Rad GTPase shRNA Plasmid (h) - sc-61433-SH from Santa Cruz Biotechnology
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Rad GTPase shRNA (h) Lentiviral Particles - sc-61433-V from Santa Cruz Biotechnology
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RRAD RNAi - H00006236-R01 from Novus Biologicals
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MISSION® esiRNA - EHU052961 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18675 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18675 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR03219 from Sigma-Aldrich
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RRAD siRNA (Human) - CRH4199 from Cohesion Biosciences
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RRAD - MBS8215484 from MyBioSource
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shRNA set against Human RRAD (NM_004165.2) - SHH399832 from Creative biogene
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Human RRAD siRNA - orb264701 from Biorbyt
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RRAD shRNA Plasmid (Human) - CHH4199 from Cohesion Biosciences
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RRAD miRNA 3'UTR clone - MiUTR3H-01978 from Creative biogene
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RRAD miRNA 3'UTR clone - MiUTR3H-01979 from Creative biogene
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