Gene Symbol | RRAD |
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Entrez Gene | 6236 |
Alt Symbol | RAD, RAD1, REM3 |
Species | Human |
Gene Type | protein-coding |
Description | Ras-related associated with diabetes |
Other Description | GTP-binding protein RAD|RAS (RAD and GEM) like GTP binding 3|ras associated with diabetes |
Swissprots | Q96F39 P55042 |
Accessions | AAB17064 EAW83053 EAW83054 EAW83055 P55042 AK290613 BAF83302 BC011645 AAH11645 BC057815 AAH57815 BP257026 DQ891951 ABM82877 DQ895137 ABM86063 L24564 AAA36540 N93445 NM_001128850 NP_001122322 NM_004165 NP_004156 |
Function | May play an important role in cardiac antiarrhythmia via the strong suppression of voltage-gated L-type Ca(2+) currents. Regulates voltage-dependent L-type calcium channel subunit alpha- 1C trafficking to the cell membrane (By similarity). Inhibits cardiac hypertrophy through the calmodulin-dependent kinase II (CaMKII) pathway. Inhibits phosphorylation and activation of CAMK2D. {ECO:0000250, ECO:0000269|PubMed:18056528}. |
Subcellular Location | Cell membrane {ECO:0000250}. |
Tissue Specificity | Most abundantly expressed in the heart. Also found in the skeletal muscle and lung. Lesser amounts in placenta and kidney. Also detected in adipose tissue. Overexpressed in muscle of type II diabetic humans. {ECO:0000269|PubMed:18056528}. |
Human RRAD protein fragment - ab114746 from Abcam
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RRAD peptide - ab95049 from Abcam
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RRAD Antibody Blocking Peptide - LS-E27851 from LifeSpan Bioscience
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RRAD Antibody Blocking Peptide - LS-E20559 from LifeSpan Bioscience
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RRAD Antibody Blocking Peptide - LS-E20558 from LifeSpan Bioscience
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Recombinant Human RRAD Protein - H00006236-Q01 from Novus Biologicals
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RRAD Blocking Peptide - 33R-4793 from Fitzgerald
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RRAD Blocking Peptide - 33R-10070 from Fitzgerald
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RRAD Blocking Peptide - abx063234 from Abbexa
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RRAD Peptide - AC21-2862-P from Abcore
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RRAD / RAD - H00006236-Q01-10 from Acris Antibodies
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RRAD / RAD - H00006236-Q01-25 from Acris Antibodies
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RRAD Peptide - 43-008P from ProSci
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Recombinant Human RRAD - RRAD-30772TH from Creative Biomart
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RRAD Blocking Peptide - CBP2040 from Cohesion Biosciences
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Rad GTPase (L80) Peptide - BS3133P from Bioworld Technology
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Recombinant Human GTP-binding protein RAD(RRAD) - CSB-YP020507HU CSB-EP020507HU CSB-BP020507HU CSB-MP020507HU from Cusabio
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RRAD / RAD (transcript variant 2) - TP302927 from Acris Antibodies
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RRAD / RAD (transcript variant 1) - TP325433 from Acris Antibodies
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RRAD, Peptide - MBS427795 from MyBioSource
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RRAD Recombinant Protein Antigen - NBP2-13266PEP from Novus Biologicals
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RRAD Peptide, Human - M34GP13616H from Creative Peptides
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GTP-binding protein RAD (RRAD), Recombinant Protein - MBS965065 from MyBioSource
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RRAD fusion protein - Ag26880 from Proteintech Group
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