MED8

Gene Symbol	MED8
Entrez Gene	112950
Alt Symbol	ARC32
Species	Human
Gene Type	protein-coding
Description	mediator complex subunit 8
Other Description	activator-recruited cofactor 32 kDa component|mediator of RNA polymerase II transcription subunit 8|mediator of RNA polymerase II transcription subunit MED8
Swissprots	A9IZ92 Q96FQ4 Q5JUY8 A9IZ91 Q96G25
Accessions	CCQ43950 EAX07099 Q96G25 AF521562 AAM76709 AV684532 BC010019 AAH10019 BC010543 AAH10543 BF196855 BG620658 BI488866 CB161514 CB162354 DQ891788 ABM82714 DQ896829 ABM87828 NM_001001653 NP_001001653 NM_052877 NP_443109 NM_201542 NP_963836
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MED8 full length protein - ab164990 from Abcam Category Protein Source Wheat germ Species Human

Human MED8 protein fragment - ab164991 from Abcam Category Protein Source Wheat germ Species Human

MED8 Antibody Blocking Peptide - LS-E1836 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MED8 Antibody Blocking Peptide - LS-E18864 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human MED8 Protein - H00112950-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human MED8 Protein - H00112950-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

MED8-Antibody-Center-Blocking-peptide - BP12649c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MED8 Blocking Peptide - 33R-6339 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

MED8 - H00112950-P01 from Acris Antibodies Category Protein Prices $310.00 Sizes 2 µg Species Human

MED8 - H00112950-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

MED8 - H00112950-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MED8 fusion protein - ag2827 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Mediator of RNA polymerase II transcription subunit 8(MED8) - CSB-YP850297HU CSB-EP850297HU CSB-BP850297HU CSB-MP850297HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Mediator of RNA polymerase II transcription subunit 8(mdt-8) - CSB-YP013668CXX CSB-EP013668CXX CSB-BP013668CXX CSB-MP013668CXX from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Caenorhabditis

MED8 (transcript variant 1) - TP304026 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

MED8 Recombinant Protein Antigen - NBP1-89015PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MED8 Recombinant Protein Antigen - NBP1-89014PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

MED8 Peptide, Human - M34GP09380H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Mediator Complex Subunit 8 (MED8) - RPU51649 from Biomatik Category Protein Prices $176.00, $360.00, $550.00, $656.00 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Human

Mediator Complex Subunit 8 (MED8), Recombinant Protein - MBS2086879 from MyBioSource Category Protein Prices $175.00, $360.00, $560.00 Sizes 10 µg, 50 µg, 100 µg Source E Coli Species Human

Mediator of RNA polymerase II transcription subunit 8 (mdt-8), Recombinant Protein - MBS1025009 from MyBioSource Category Protein Prices $1,050.00, $1,050.00, $1,280.00, $1,280.00, $1,635.00, $1,635.00, $2,100.00, $2,100.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Caenorhabditis

Mediator of RNA polymerase II transcription subunit 8 (med-8), Recombinant Protein - MBS1488046 from MyBioSource Category Protein Prices $1,030.00, $1,030.00, $1,260.00, $1,260.00, $1,595.00, $1,595.00, $2,060.00, $2,060.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Neurospora crassa

Mediator of RNA polymerase II transcription subunit 8 (MED8), Recombinant Protein - MBS1337866 from MyBioSource Category Protein Prices $1,020.00, $1,020.00, $1,250.00, $1,250.00, $1,575.00, $1,575.00, $2,040.00, $2,040.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Mediator of RNA polymerase II transcription subunit 8 (med8), Recombinant Protein - MBS1284899 from MyBioSource Category Protein Prices $1,010.00, $1,010.00, $1,240.00, $1,240.00, $1,555.00, $1,555.00, $2,020.00, $2,020.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Emericella

Mediator of RNA polymerase II transcription subunit 8 (MED8), Recombinant Protein - MBS1426489 from MyBioSource Category Protein Prices $940.00, $940.00, $1,165.00, $1,165.00, $1,400.00, $1,400.00, $1,865.00, $1,865.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Yarrowia

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