MED8

Gene Symbol	MED8
Entrez Gene	112950
Alt Symbol	ARC32
Species	Human
Gene Type	protein-coding
Description	mediator complex subunit 8
Other Description	activator-recruited cofactor 32 kDa component|mediator of RNA polymerase II transcription subunit 8|mediator of RNA polymerase II transcription subunit MED8
Swissprots	A9IZ92 Q96FQ4 Q5JUY8 A9IZ91 Q96G25
Accessions	CCQ43950 EAX07099 Q96G25 AF521562 AAM76709 AV684532 BC010019 AAH10019 BC010543 AAH10543 BF196855 BG620658 BI488866 CB161514 CB162354 DQ891788 ABM82714 DQ896829 ABM87828 NM_001001653 NP_001001653 NM_052877 NP_443109 NM_201542 NP_963836
Function	Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.
Subcellular Location	Nucleus {ECO:0000305}.
Top Pathways	Herpes simplex infection

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Med8 CRISPR/Cas9 KO Plasmid (h) - sc-404402 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 HDR Plasmid (h) - sc-404402-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 Double Nickase Plasmid (h) - sc-404402-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 Double Nickase Plasmid (h2) - sc-404402-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 CRISPR Activation Plasmid (h) - sc-404402-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 CRISPR Activation Plasmid (h2) - sc-404402-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 Lentiviral Activation Particles (h) - sc-404402-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 Lentiviral Activation Particles (h2) - sc-404402-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 siRNA (h) - sc-88195 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Med8 shRNA Plasmid (h) - sc-88195-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Med8 shRNA (h) Lentiviral Particles - sc-88195-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MED8 RNAi - H00112950-R10 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MED8 RNAi - H00112950-R07 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MED8 RNAi - H00112950-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MED8 RNAi - H00112950-R09 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MED8 RNAi - H00112950-R06 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU132481 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN13184 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13184 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR08228 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr08228

MED8 siRNA (Human) - CRJ4303 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Med8 CRISPR/Cas9 KO Plasmid (h2) - sc-404402-KO-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Med8 HDR Plasmid (h2) - sc-404402-HDR-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

shRNA set against Human MED8 (NM_201542.3) - SHH340151 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MED8(NM_201542.3) - SHH183723 from Creative biogene Category siRNA Species Reactivities Human

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