REC8

Gene Symbol	REC8
Entrez Gene	9985
Alt Symbol	HR21spB, REC8L1, Rec8p
Species	Human
Gene Type	protein-coding
Description	REC8 meiotic recombination protein
Other Description	REC8 homolog|REC8-like 1|cohesin Rec8p|cohesion rec8p|human homolog of rad21, S. pombe|kleisin-alpha|meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family|meiotic recombination protein REC8 homolog|meiotic recombination protein REC8-like 1|recombination and sister chromatid cohesion protein homolog
Swissprots	Q9BTF2 A8K576 O95072 Q6IA92 Q658V5 D3DS62 Q8WUV8 Q9NVQ9
Accessions	EAW66089 EAW66090 EAW66091 O95072 AA496891 AF006264 AAD01193 AK001435 BAA91690 AK291191 BAF83880 AL832973 CAH56339 BC004159 AAH04159 BC010887 AAH10887 BC019326 AAH19326 CR457263 CAG33544 DB294585 XM_011537421 XP_011535723 XM_011537422 XP_011535724 XM_011537423 XP_011535725 XR_943567 XR_943568 NM_001048205 NP_001041670 NM_005132 NP_005123
Function	Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity). Localised to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250}.
Tissue Specificity	Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level). {ECO:0000269|PubMed:10207075}.
Top Pathways	Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rec8 (C-16) - sc-15154 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rec8 (E-18) - sc-15152 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Rec8 (H-100) - sc-366993 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-REC8 antibody - ab83798 from Abcam Prices $376.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-REC8 antibody - ab138012 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-REC8 antibody - ab169367 from Abcam Prices $376.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-REC8 antibody [EPR16189] - ab192241 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR16189

Anti-REC8 Antibody (phospho-Ser251) - LS-C47114 from LifeSpan Bioscience Prices $295.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, AP) - LS-C239896 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, APC) - LS-C239898 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa137-186) - LS-C200578 from LifeSpan Bioscience Prices $315.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, Biotin) - LS-C239899 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, FITC) - LS-C239900 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, PE) - LS-C239902 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222, Azide-free, HRP) - LS-C248643 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa193-222) - LS-C324600 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa72-121) - LS-C102282 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-REC8 Antibody (aa194-222) - LS-C162527 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

REC8 Antibody - NBP1-87145 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

REC8 Antibody - NBP1-87144 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

REC8 Antibody (2G3) - H00009985-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 2G3

REC8 Antibody - H00009985-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

REC8 Polyclonal Antibody - bs-7723R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

REC8(Ser251) Polyclonal Antibody - bs-7726R from Bioss Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-REC8 antibody produced in rabbit - SAB2101975 from Sigma-Aldrich Prices $347.50 Sizes 50 µg Host Rabbit Clonality Polyclonal

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