REC8

Gene Symbol	REC8
Entrez Gene	9985
Alt Symbol	HR21spB, REC8L1, Rec8p
Species	Human
Gene Type	protein-coding
Description	REC8 meiotic recombination protein
Other Description	REC8 homolog|REC8-like 1|cohesin Rec8p|cohesion rec8p|human homolog of rad21, S. pombe|kleisin-alpha|meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family|meiotic recombination protein REC8 homolog|meiotic recombination protein REC8-like 1|recombination and sister chromatid cohesion protein homolog
Swissprots	Q9BTF2 A8K576 O95072 Q6IA92 Q658V5 D3DS62 Q8WUV8 Q9NVQ9
Accessions	EAW66089 EAW66090 EAW66091 O95072 AA496891 AF006264 AAD01193 AK001435 BAA91690 AK291191 BAF83880 AL832973 CAH56339 BC004159 AAH04159 BC010887 AAH10887 BC019326 AAH19326 CR457263 CAG33544 DB294585 XM_011537421 XP_011535723 XM_011537422 XP_011535724 XM_011537423 XP_011535725 XR_943567 XR_943568 NM_001048205 NP_001041670 NM_005132 NP_005123
Function	Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity). Localised to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250}.
Tissue Specificity	Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level). {ECO:0000269|PubMed:10207075}.
Top Pathways	Oocyte meiosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human REC8 full length protein - ab132427 from Abcam Category Protein Source Wheat germ Species Human

Human REC8 protein fragment - ab160744 from Abcam Category Protein Source Wheat germ Species Human

Mouse REC8 peptide - ab38371 from Abcam Category Peptide

REC8 Antibody Blocking Peptide - LS-E2533 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

REC8 Antibody Blocking Peptide - LS-E17382 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human REC8 Protein - H00009985-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human REC8 Protein - H00009985-Q01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

REC8-Antibody-Center-Blocking-peptide - BP13570c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Rec8 Blocking Peptide - 33R-7641 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

REC8 - H00009985-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

REC8 - H00009985-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

REC8 - H00009985-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

REC8 - H00009985-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

REC8 fusion protein - ag13092 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

REC8 fusion protein - ag1250 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Meiotic recombination protein REC8 homolog(REC8) - CSB-YP019535HU CSB-EP019535HU CSB-BP019535HU CSB-MP019535HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

REC8 (transcript variant 1) - TP300132 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

REC8 Recombinant Protein Antigen - NBP1-87145PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

REC8 Recombinant Protein Antigen - NBP1-87144PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

REC8 Peptide, Human - M34GP13138H from Creative Peptides Category Peptide Source Synthetic. Species Human

Meiotic recombination protein REC8 homolog (REC8), Recombinant Protein - MBS1182113 from MyBioSource Category Protein Prices $1,340.00, $1,340.00, $1,560.00, $1,560.00, $2,220.00, $2,220.00, $2,685.00, $2,685.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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