| Gene Symbol | REC8 |
|---|---|
| Entrez Gene | 9985 |
| Alt Symbol | HR21spB, REC8L1, Rec8p |
| Species | Human |
| Gene Type | protein-coding |
| Description | REC8 meiotic recombination protein |
| Other Description | REC8 homolog|REC8-like 1|cohesin Rec8p|cohesion rec8p|human homolog of rad21, S. pombe|kleisin-alpha|meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family|meiotic recombination protein REC8 homolog|meiotic recombination protein REC8-like 1|recombination and sister chromatid cohesion protein homolog |
| Swissprots | Q9BTF2 A8K576 O95072 Q6IA92 Q658V5 D3DS62 Q8WUV8 Q9NVQ9 |
| Accessions | EAW66089 EAW66090 EAW66091 O95072 AA496891 AF006264 AAD01193 AK001435 BAA91690 AK291191 BAF83880 AL832973 CAH56339 BC004159 AAH04159 BC010887 AAH10887 BC019326 AAH19326 CR457263 CAG33544 DB294585 XM_011537421 XP_011535723 XM_011537422 XP_011535724 XM_011537423 XP_011535725 XR_943567 XR_943568 NM_001048205 NP_001041670 NM_005132 NP_005123 |
| Function | Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity). Localised to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250}. |
| Tissue Specificity | Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level). {ECO:0000269|PubMed:10207075}. |
| Top Pathways | Oocyte meiosis |
Rec8 CRISPR/Cas9 KO Plasmid (h) - sc-404152 from Santa Cruz Biotechnology
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Rec8 HDR Plasmid (h) - sc-404152-HDR from Santa Cruz Biotechnology
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Rec8 Double Nickase Plasmid (h) - sc-404152-NIC from Santa Cruz Biotechnology
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Rec8 Double Nickase Plasmid (h2) - sc-404152-NIC-2 from Santa Cruz Biotechnology
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Rec8 CRISPR Activation Plasmid (h) - sc-404152-ACT from Santa Cruz Biotechnology
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Rec8 CRISPR Activation Plasmid (h2) - sc-404152-ACT-2 from Santa Cruz Biotechnology
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Rec8 Lentiviral Activation Particles (h) - sc-404152-LAC from Santa Cruz Biotechnology
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Rec8 Lentiviral Activation Particles (h2) - sc-404152-LAC-2 from Santa Cruz Biotechnology
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Rec8 siRNA (h) - sc-106878 from Santa Cruz Biotechnology
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Rec8 shRNA Plasmid (h) - sc-106878-SH from Santa Cruz Biotechnology
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Rec8 shRNA (h) Lentiviral Particles - sc-106878-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU047941 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN18118 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18118 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00426 from Sigma-Aldrich
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REC8 siRNA (Human) - CRH6717 from Cohesion Biosciences
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REC8 - MBS8212158 from MyBioSource
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shRNA set against Human REC8 (NM_005132.2) - SHH391576 from Creative biogene
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shRNA set against Human REC8(NM_001048205.1) - SHR174714 from Creative biogene
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Human REC8 siRNA - orb267219 from Biorbyt
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REC8 shRNA Plasmid (Human) - CHH6717 from Cohesion Biosciences
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REC8 miRNA 3'UTR clone - MiUTR1H-08725 from Creative biogene
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REC8 miRNA 3'UTR clone - MiUTR3H-09833 from Creative biogene
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