REC8

Gene Symbol REC8
Entrez Gene 9985
Alt Symbol HR21spB, REC8L1, Rec8p
Species Human
Gene Type protein-coding
Description REC8 meiotic recombination protein
Other Description REC8 homolog|REC8-like 1|cohesin Rec8p|cohesion rec8p|human homolog of rad21, S. pombe|kleisin-alpha|meiotic recombination and sister chromatid cohesion phosphoprotein of the rad21p family|meiotic recombination protein REC8 homolog|meiotic recombination protein REC8-like 1|recombination and sister chromatid cohesion protein homolog
Swissprots Q9BTF2 A8K576 O95072 Q6IA92 Q658V5 D3DS62 Q8WUV8 Q9NVQ9
Accessions EAW66089 EAW66090 EAW66091 O95072 AA496891 AF006264 AAD01193 AK001435 BAA91690 AK291191 BAF83880 AL832973 CAH56339 BC004159 AAH04159 BC010887 AAH10887 BC019326 AAH19326 CR457263 CAG33544 DB294585 XM_011537421 XP_011535723 XM_011537422 XP_011535724 XM_011537423 XP_011535725 XR_943567 XR_943568 NM_001048205 NP_001041670 NM_005132 NP_005123
Function Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Chromosome {ECO:0000250}. Note=In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chromosomes including both centromere and arm regions. No longer detected in arm regions in anaphase I but persists on centromere regions until metaphase II (By similarity). Localised to centromeres and spindle poles in endopolyploid tumor cells. {ECO:0000250}.
Tissue Specificity Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa (at protein level). {ECO:0000269|PubMed:10207075}.
Top Pathways Oocyte meiosis

REC8 overexpression lysate - LY401575 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

REC8 overexpression lysate - LY420781 from Acris Antibodies

Category Cell Lysate
Prices $480.00
Sizes 100 µg

REC8 293 Cell Lysate - 401428 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

REC8 293 Cell Lysate - 409448 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

REC8 Overexpression Lysate (Native) - NBL1-15263 from Novus Biologicals

Category Cell Lysate
Prices $529.00
Sizes 100 µg
Western Blot: REC8 Overexpression Lysate (Adult Normal) [NBL1-15263] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for REC8.

REC8 Overexpression Lysate (Native) - NBL1-15262 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: REC8 Overexpression Lysate (Adult Normal) [NBL1-15262] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for REC8.

REC8 Over-expression Lysate Product - GWB-DA753F from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

REC8 Over-expression Lysate Product - GWB-2107EB from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

REC8 Overexpression Lysate (Denatured) - H00009985-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human REC8 Knockdown Stable Cell Line - CSC-DC013138 from Creative biogene

Category Cell Line
Species Human
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