Gene Symbol |
IRF6
|
Entrez Gene |
3664
|
Alt Symbol |
LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1
|
Species |
Human
|
Gene Type |
protein-coding
|
Description |
interferon regulatory factor 6
|
Other Description |
-
|
Swissprots |
G0ZTL0 D3DT90 B4DLE2 F5GWX8 O14896
|
Accessions |
AEK31251 AEL89176 EAW93438 EAW93439 O14896 AF027292 AAB84111 AK296960 BAG59504 AK312857 BAG35709 BC014852 AAH14852 BI770148 DA016081 NM_001206696 NP_001193625 NM_006147 NP_006138
|
Function |
Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}.
|
Subcellular Location |
Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}.
|
Tissue Specificity |
Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. {ECO:0000269|PubMed:16049006}.
|