Gene Symbol | IRF6 |
---|---|
Entrez Gene | 3664 |
Alt Symbol | LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1 |
Species | Human |
Gene Type | protein-coding |
Description | interferon regulatory factor 6 |
Other Description | - |
Swissprots | G0ZTL0 D3DT90 B4DLE2 F5GWX8 O14896 |
Accessions | AEK31251 AEL89176 EAW93438 EAW93439 O14896 AF027292 AAB84111 AK296960 BAG59504 AK312857 BAG35709 BC014852 AAH14852 BI770148 DA016081 NM_001206696 NP_001193625 NM_006147 NP_006138 |
Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}. |
Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. {ECO:0000269|PubMed:16049006}. |