Gene Symbol | IRF6 |
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Entrez Gene | 3664 |
Alt Symbol | LPS, OFC6, PIT, PPS, PPS1, VWS, VWS1 |
Species | Human |
Gene Type | protein-coding |
Description | interferon regulatory factor 6 |
Other Description | - |
Swissprots | G0ZTL0 D3DT90 B4DLE2 F5GWX8 O14896 |
Accessions | AEK31251 AEL89176 EAW93438 EAW93439 O14896 AF027292 AAB84111 AK296960 BAG59504 AK312857 BAG35709 BC014852 AAH14852 BI770148 DA016081 NM_001206696 NP_001193625 NM_006147 NP_006138 |
Function | Probable DNA-binding transcriptional activator. Key determinant of the keratinocyte proliferation-differentiation switch involved in appropriate epidermal development (By similarity). Plays a role in regulating mammary epithelial cell proliferation (By similarity). May regulate WDR65 transcription (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:16049006, ECO:0000269|PubMed:18212048}. Note=Translocates to nucleus in response to an activating signal. {ECO:0000250}. |
Tissue Specificity | Expressed in normal mammary epithelial cells. Expression is reduced or absent in breast carcinomas. {ECO:0000269|PubMed:16049006}. |
IRF-6 CRISPR/Cas9 KO Plasmid (h) - sc-407198 from Santa Cruz Biotechnology
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IRF-6 HDR Plasmid (h) - sc-407198-HDR from Santa Cruz Biotechnology
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IRF-6 Double Nickase Plasmid (h) - sc-407198-NIC from Santa Cruz Biotechnology
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IRF-6 Double Nickase Plasmid (h2) - sc-407198-NIC-2 from Santa Cruz Biotechnology
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IRF-6 CRISPR Activation Plasmid (h) - sc-407198-ACT from Santa Cruz Biotechnology
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IRF-6 CRISPR Activation Plasmid (h2) - sc-407198-ACT-2 from Santa Cruz Biotechnology
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IRF-6 Lentiviral Activation Particles (h) - sc-407198-LAC from Santa Cruz Biotechnology
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IRF-6 Lentiviral Activation Particles (h2) - sc-407198-LAC-2 from Santa Cruz Biotechnology
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IRF-6 siRNA (h) - sc-105582 from Santa Cruz Biotechnology
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IRF-6 shRNA Plasmid (h) - sc-105582-SH from Santa Cruz Biotechnology
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IRF-6 shRNA (h) Lentiviral Particles - sc-105582-V from Santa Cruz Biotechnology
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IRF6 RNAi - H00003664-R01 from Novus Biologicals
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MISSION® esiRNA - EHU054271 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10768 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10768 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR04413 from Sigma-Aldrich
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IRF6 siRNA (Human) - CRH2457 from Cohesion Biosciences
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IRF6 - MBS8232636 from MyBioSource
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shRNA set against Human IRF6 (NM_006147.3) - SHH320641 from Creative biogene
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Human IRF6 siRNA - orb262959 from Biorbyt
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IRF6 shRNA Plasmid (Human) - CHH2457 from Cohesion Biosciences
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IRF6 miRNA 3'UTR clone - MiUTR3H-09038 from Creative biogene
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