UHRF1

Gene Symbol UHRF1
Entrez Gene 29128
Alt Symbol ICBP90, Np95, RNF106, hNP95, hUHRF1, huNp95
Species Human
Gene Type protein-coding
Description ubiquitin-like with PHD and ring finger domains 1
Other Description E3 ubiquitin-protein ligase UHRF1|RING finger protein 106|inverted CCAAT box-binding protein of 90 kDa|nuclear phosphoprotein 95|nuclear protein 95|nuclear zinc finger protein Np95|transcription factor ICBP90|ubiquitin-like PHD and RING finger domain-containing protein 1
Swissprots Q9P1U7 Q2HIX7 Q9P115 Q8J022 B2RBA9 A0JBR2 Q9H6S6 Q96T88 A8K024
Accessions AAF64067 AAV40831 BAC20576 CCQ43417 EAW69187 EAW69188 EAW69189 Q96T88 AA026356 AB177623 BAF36719 AB177624 BAF36720 AF129507 AAF28469 AF274048 AAK55744 AK025578 BAB15177 AK074377 AK289389 BAF82078 AK303361 BAG64421 AK307239 AK314579 BAG37156 BC039136 BC046179 BC113875 AAI13876 CN335888 DA451120 EF560733 ABQ59043 EU446794 ABZ92323 HY074450 XM_011527942 XP_011526244 NM_001048201 NP_001041666 NM_001290050 NP_001276979 NM_001290051 NP_001276980 NM_001290052 NP_001276981 NM_013282 NP_037414
Function Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21777816}. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
Tissue Specificity Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:12838312, ECO:0000269|PubMed:15361834}.

UHRF1 (D6G8E) Rabbit mAb - 12387 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D6G8E
Western blot analysis of extracts from various cell lines using UHRF1 (D6G8E) Rabbit mAb.

UHRF1 (G-3) - sc-365392 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UHRF1 (G-3): sc-365392. Western blot analysis of UHRF1 expression in non-transfected: sc-117752 (A) and mouse UHRF1 transfected: sc-124463 (B) 293T whole cell lysates.

UHRF1 (G-2) - sc-166898 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UHRF1 (G-2): sc-166898. Western blot analysis of UHRF1 expression in MDA-MB-231 whole cell lysate.

UHRF1 (E-15) - sc-79806 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UHRF1 (E-15): sc-79806. Western blot analysis of UHRF1 expression in non-transfected: sc-117752 (A) and mouse UHRF1 transfected: sc-124463 (B) 293T whole cell lysates.

UHRF1 (C-9) - sc-365391 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UHRF1 (C-9): sc-365391. Western blot analysis of UHRF1 expression in non-transfected: sc-117752 (A) and mouse UHRF1 transfected: sc-124463 (B) 293T whole cell lysates.

UHRF1 (H-65) - sc-98704 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UHRF1 (H-65): sc-98704. Western blot analysis of UHRF1 expression in HS 181.Tes whole cell lysate.

UHRF1 (C-12) - sc-79805 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UHRF1 (C-12): sc-79805. Western blot analysis of UHRF1 expression in non-transfected: sc-117752 (A) and mouse UHRF1 transfected: sc-124463 (B) 293T whole cell lysates.

UHRF1 (28) - sc-136264 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/0.5 ml
Host Mouse
Clonality Monoclonal
UHRF1 (28): sc-136264. Western blot analysis of UHRF1 expression in HeLa whole cell lysate.

Anti-UHRF1 antibody - ab57083 from Abcam

Prices $390.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
UHRF1 antibody (ab57083) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human endometrium.

Anti-UHRF1 antibody - ab153972 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-UHRF1 antibody (ab153972) at 1/2000 dilution + HeLa whole cell lysate at 30 µg

Anti-UHRF1 antibody - ab126243 from Abcam

Prices $376.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-UHRF1 antibody (ab126243) at 1/1000 dilution + HCT116 whole cell lysate at 30 µg

Anti-UHRF1 antibody - ab93419 from Abcam

Prices $359.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-UHRF1 antibody (ab93419) at 1/100 dilution + HeLa cell lysate at 35 µg

Anti-UHRF1 antibody - ab100810 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Staining of Human UHRF1 in a Formalin/PFA-fixed paraffin-embedded section of Human Basal Cell Carcinoma using ab100810 at a dilution of 1/250.

Anti-UHRF1 antibody - ab43682 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-UHRF1 antibody (ab43682) at 1/1000 dilutionLane 1 : 20µg of a total protein extract from E coli with ~50ng to 500ng of a tagged fusion protein of an irrelevant antigen.Lane 2 : 20µg of a total protein extract from E coli with ~50ng to 500ng of the antigen (Tagged fusion protein). SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated, at 1/5000 dilution

Anti-UHRF1 antibody - ab94464 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-UHRF1 antibody (ab94464) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal stomach lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-UHRF1 antibody - ab99555 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UHRF1 antibody [1H9-D3-E11] - ab151187 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1H9-D3-E11
All lanes : Anti-UHRF1 antibody [1H9-D3-E11] (ab151187) at 1/1000 dilutionLane 1 : Mouse heart cell lysateLane 2 : 293T cell lysateLane 3 : HeLaNE cell lysateLane 4 : Hela cell lysate

Anti-UHRF1 Antibody (aa795-806) - LS-C186521 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-UHRF1 Antibody (clone mt40) - LS-C193590 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone mt40

Anti-UHRF1 Antibody (N-Terminus) - LS-C110343 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
UHRF1 antibody LS-C110343 Western blot of Fetal Stomach lysate.

Anti-UHRF1 Antibody (Internal, AP) - LS-C246302 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UHRF1 Antibody (Internal, APC) - LS-C246303 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UHRF1 Antibody (Internal, FITC) - LS-C246304 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UHRF1 Antibody (Internal, PE) - LS-C246305 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UHRF1 Antibody (clone Th-10a) - LS-C179534 from LifeSpan Bioscience

Prices $380.00
Sizes 100 µl
Host Rat
Clonality Monoclonal
Clone Th-10a
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