UHRF1

Gene Symbol	UHRF1
Entrez Gene	29128
Alt Symbol	ICBP90, Np95, RNF106, hNP95, hUHRF1, huNp95
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like with PHD and ring finger domains 1
Other Description	E3 ubiquitin-protein ligase UHRF1|RING finger protein 106|inverted CCAAT box-binding protein of 90 kDa|nuclear phosphoprotein 95|nuclear protein 95|nuclear zinc finger protein Np95|transcription factor ICBP90|ubiquitin-like PHD and RING finger domain-containing protein 1
Swissprots	Q9P1U7 Q2HIX7 Q9P115 Q8J022 B2RBA9 A0JBR2 Q9H6S6 Q96T88 A8K024
Accessions	AAF64067 AAV40831 BAC20576 CCQ43417 EAW69187 EAW69188 EAW69189 Q96T88 AA026356 AB177623 BAF36719 AB177624 BAF36720 AF129507 AAF28469 AF274048 AAK55744 AK025578 BAB15177 AK074377 AK289389 BAF82078 AK303361 BAG64421 AK307239 AK314579 BAG37156 BC039136 BC046179 BC113875 AAI13876 CN335888 DA451120 EF560733 ABQ59043 EU446794 ABZ92323 HY074450 XM_011527942 XP_011526244 NM_001048201 NP_001041666 NM_001290050 NP_001276979 NM_001290051 NP_001276980 NM_001290052 NP_001276981 NM_013282 NP_037414
Function	Multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Specifically recognizes and binds hemimethylated DNA at replication forks via its YDG domain and recruits DNMT1 methyltransferase to ensure faithful propagation of the DNA methylation patterns through DNA replication. In addition to its role in maintenance of DNA methylation, also plays a key role in chromatin modification: through its tudor-like regions and PHD- type zinc fingers, specifically recognizes and binds histone H3 trimethylated at 'Lys-9' (H3K9me3) and unmethylated at 'Arg-2' (H3R2me0), respectively, and recruits chromatin proteins. Enriched in pericentric heterochromatin where it recruits different chromatin modifiers required for this chromatin replication. Also localizes to euchromatic regions where it negatively regulates transcription possibly by impacting DNA methylation and histone modifications. Has E3 ubiquitin-protein ligase activity by mediating the
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00358, ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:17673620, ECO:0000269|PubMed:17967883, ECO:0000269|PubMed:19056828, ECO:0000269|PubMed:21777816}. Note=Localizes to replication foci. Enriched in pericentric heterochromatin. Also localizes to euchromatic regions.
Tissue Specificity	Expressed in thymus, bone marrow, testis, lung and heart. Overexpressed in breast cancer. {ECO:0000269|PubMed:10646863, ECO:0000269|PubMed:12838312, ECO:0000269|PubMed:15361834}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human UHRF1 full length protein - ab198770 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human UHRF1 protein fragment - ab112411 from Abcam Category Protein Source Wheat germ Species Human

Human UHRF1 protein fragment - ab198763 from Abcam Category Protein Source E. coli Species Human

Human UHRF1 protein fragment - ab198768 from Abcam Category Protein Source E. coli Species Human

UHRF1 Antibody Blocking Peptide - LS-E25540 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UHRF1 Antibody Blocking Peptide - LS-E14073 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UHRF1 Antibody Blocking Peptide - LS-E9813 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human UHRF1 Protein - H00029128-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

UHRF1-Antibody-Center-Blocking-Peptide - BP8846c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UHRF1 Blocking Peptide - abx063835 from Abbexa Category Peptide Species Human

UHRF1 Peptide - AC21-2799-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

UHRF1 - H00029128-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UHRF1 - H00029128-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UHRF1 fusion protein - Ag17498 from Proteintech Group Category Protein Source E. coli -derived, PET28a Species Human

UHRF1 fusion protein - Ag16111 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human UHRF1 - UHRF1-31665TH from Creative Biomart Category Protein Source Wheat germ Species Human

UHRF1 Blocking Peptide - CBP2641 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Recombinant Human E3 ubiquitin-protein ligase UHRF1(UHRF1) - CSB-YP847229HU CSB-EP847229HU CSB-BP847229HU CSB-MP847229HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

UHRF1 (transcript variant 2) - TP314251 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

ICBP90 / UHRF1, Peptide - MBS427844 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Rat, Dog

ICBP90/UHRF1, Peptide - MBS428039 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog

Recombinant Human UHRF1 Protein, GST-tagged - UHRF1-233H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human UHRF1 Protein, His-tagged - UHRF1-234H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human UHRF1 Protein, GST-tagged - UHRF1-235H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human UHRF1 Protein, His-tagged - UHRF1-236H from Creative Biomart Category Protein Source E. coli Species Human

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