| Gene Symbol |
NENF
|
| Entrez Gene |
29937
|
| Alt Symbol |
CIR2, SCIRP10, SPUF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
neudesin neurotrophic factor
|
| Other Description |
SCIRP10-related protein|Spinal cord injury related protein 10|cell growth-inhibiting protein 47|cell immortalization-related protein 2|neudesin|neuron-derived neurotrophic factor|secreted protein of unknown function
|
| Swissprots |
Q53FZ6 Q5TM90 A1KYQ8 Q9UMX5
|
| Accessions |
EAW93389 Q9UMX5 AB126219 BAD72063 AF000267 AF049672 AF173937 AAD51419 AK074431 AK223135 BAD96855 AY762102 AAX07829 BC008823 AAH08823 DB502983 DB574171 NM_013349 NP_037481 NR_026598
|
| Function |
Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:22748190}.
|
| Subcellular Location |
Secreted, extracellular space {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast. {ECO:0000269|PubMed:22748190}.
|