NENF

Gene Symbol NENF
Entrez Gene 29937
Alt Symbol CIR2, SCIRP10, SPUF
Species Human
Gene Type protein-coding
Description neudesin neurotrophic factor
Other Description SCIRP10-related protein|Spinal cord injury related protein 10|cell growth-inhibiting protein 47|cell immortalization-related protein 2|neudesin|neuron-derived neurotrophic factor|secreted protein of unknown function
Swissprots Q53FZ6 Q5TM90 A1KYQ8 Q9UMX5
Accessions EAW93389 Q9UMX5 AB126219 BAD72063 AF000267 AF049672 AF173937 AAD51419 AK074431 AK223135 BAD96855 AY762102 AAX07829 BC008823 AAH08823 DB502983 DB574171 NM_013349 NP_037481 NR_026598
Function Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:22748190}.
Subcellular Location Secreted, extracellular space {ECO:0000250}.
Tissue Specificity Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast. {ECO:0000269|PubMed:22748190}.

Neudesin (C-19) - sc-163129 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neudesin (T-16) - sc-163130 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Neudesin (V-12) - sc-163131 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-NENF antibody - ab74474 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of NENF in rat kidney tissue with ab74474 at 20 ug/mL.

Anti-NENF / Neudesin Antibody (aa32-172) - LS-C184854 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Sheep
Clonality Polyclonal

Anti-NENF / Neudesin Antibody (aa149-160) - LS-C55160 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-NENF / Neudesin Antibody (aa38-87) - LS-C187368 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human Fetal Heart. NENF antibody dilution 1.0 ug/ml.

Anti-NENF / Neudesin Antibody - LS-C346309 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Western blot blot of extracts of Human brain cell line, using NENF antibody.

Anti-NENF / Neudesin Antibody (C-Terminus) IHC-plus™ - LS-B4988 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-NENF antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4988 concentration 5 ug/ml.

Neudesin Antibody (737130) - MAB6714 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Mouse
Clonality Monoclonal
Clone 737130

Neudesin Antibody - NBP1-77331 from Novus Biologicals

Prices $329.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western Blot: Neudesin Antibody [NBP1-77331] - Human kidney tissue lysate with NENF antibody at (A) 1 and (B) 2 ug/mL.

Neudesin Antibody - AF6714 from Novus Biologicals

Prices $99.00, $359.00
Sizes 25 µg, 100 µg
Host Sheep
Clonality Polyclonal
Neudesin was detected in immersion fixed paraffin-embedded sections of human brain (medulla) using Sheep Anti-Human Neudesin Antigen Affinity-purified Polyclonal Antibody (Catalog # AF6714) at 10 µg/mL overnight at 4 °C. Before incubation with the primary antibody, tissue was subjected to heat-induced epitope retrieval using Antigen Retrieval Reagent-Basic (Catalog # CTS013). Tissue was stained using the Anti-Sheep HRP-DAB Cell & Tissue Staining Kit (brown; Catalog # CTS019) and counterstained with hematoxylin (blue). Specific staining was localized to neuronal cell bodies and processes. View our protocol for Chromogenic IHC Staining of Paraffin-embedded Tissue Sections.

Neudesin Antibody - NBP1-72108 from Novus Biologicals

Prices $399.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: NENF Antibody [NBP1-72108] - Staining of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Neudesin Antibody - NBP1-84462 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Neudesin Antibody - NBP2-13652 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Neudesin Antibody - NBP1-06056 from Novus Biologicals

Prices $229.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Neudesin Antibody (7D10) - H00029937-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 7D10

NENF/Neudesin Polyclonal Antibody - bs-11502R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-11502R-A350 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-11502R-A488 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-11502R-A555 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-11502R-A647 from Bioss

Prices $325.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, Cy3 Conjugated - bs-11502R-Cy3 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, Cy5 Conjugated - bs-11502R-Cy5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Rabbit Anti-NENF/Neudesin Polyclonal Antibody, Cy5.5 Conjugated - bs-11502R-Cy5.5 from Bioss

Prices $345.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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