Gene Symbol | NENF |
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Entrez Gene | 29937 |
Alt Symbol | CIR2, SCIRP10, SPUF |
Species | Human |
Gene Type | protein-coding |
Description | neudesin neurotrophic factor |
Other Description | SCIRP10-related protein|Spinal cord injury related protein 10|cell growth-inhibiting protein 47|cell immortalization-related protein 2|neudesin|neuron-derived neurotrophic factor|secreted protein of unknown function |
Swissprots | Q53FZ6 Q5TM90 A1KYQ8 Q9UMX5 |
Accessions | EAW93389 Q9UMX5 AB126219 BAD72063 AF000267 AF049672 AF173937 AAD51419 AK074431 AK223135 BAD96855 AY762102 AAX07829 BC008823 AAH08823 DB502983 DB574171 NM_013349 NP_037481 NR_026598 |
Function | Acts as a neurotrophic factor in postnatal mature neurons enhancing neuronal survival. Promotes cell proliferation and neurogenesis in undifferentiated neural pro-genitor cells at the embryonic stage and inhibits differentiation of astrocyte. Its neurotrophic activity is exerted via MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT pathways. Neurotrophic activity is enhanced by binding to heme. Acts also as an anorexigenic neurotrophic factor that contributes to energy balance (By similarity). Plays a role in the human tumorigenesis (PubMed:22748190). {ECO:0000250|UniProtKB:Q9CQ45, ECO:0000269|PubMed:22748190}. |
Subcellular Location | Secreted, extracellular space {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed with high expression in heart. Over-expressed in various tumors including carcinomas of the uterine cervix, lymphoma, colon, lung, skin and leukemia, as well as carcinoma of the breast. {ECO:0000269|PubMed:22748190}. |
Human NENF full length protein - ab139226 from Abcam
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NENF / Neudesin Antibody Blocking Peptide - LS-E26463 from LifeSpan Bioscience
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NENF / Neudesin Antibody Blocking Peptide - LS-E30552 from LifeSpan Bioscience
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NENF / Neudesin Antibody Blocking Peptide - LS-E24346 from LifeSpan Bioscience
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Recombinant Human Neudesin Protein - H00029937-P01 from Novus Biologicals
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Neudesin Blocking Peptide - NBP1-77331PEP from Novus Biologicals
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NENF Peptide - GTX85028-PEP from GeneTex
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Neudesin/NENF blocking peptide - GTX88949-PEP from GeneTex
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Recombinant Human Neudesin, CF - 6714-ND-050 from R&D Systems
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Human NENF protein - orb191204 from Biorbyt
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NENF Peptide - AC21-1301-P from Abcore
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Neudesin - H00029937-P01-10 from Acris Antibodies
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Neudesin - H00029937-P01-25 from Acris Antibodies
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Neudesin Control Peptide - AP30585CP-N from Acris Antibodies
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NENF Peptide - 4753P from ProSci
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Neudesin Peptide - 45-950P from ProSci
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NENF fusion protein - Ag17683 from Proteintech Group
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NENF fusion protein - Ag8387 from Proteintech Group
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Recombinant Human NENF, His-tagged - NENF-1263H from Creative Biomart
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Recombinant Neudesin Neurotrophic Factor (NENF) - RPH544Hu01 from Uscn Life Science Inc.
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Recombinant Neudesin Neurotrophic Factor (NENF) - RPH544Hu01 from Cloud-clone
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Recombinant Human Neudesin(NENF) - CSB-YP892354HU CSB-EP892354HU CSB-BP892354HU CSB-MP892354HU from Cusabio
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Recombinant Human Neudesin Protein, CF - 6714-ND from R&D Systems
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Neudesin Neurotrophic Factor Protein (Recombinant) - abx167068 from Abbexa
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Neudesin Neurotrophic Factor Protein (Recombinant) - abx262414 from Abbexa
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