| Gene Symbol |
PCSK5
|
| Entrez Gene |
5125
|
| Alt Symbol |
PC5, PC6, PC6A, SPC6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proprotein convertase subtilisin/kexin type 5
|
| Other Description |
prohormone convertase 5|proprotein convertase 6|protease PC6|subtilase|subtilisin/kexin-like protease PC5
|
| Swissprots |
F5H2G7 Q13527 Q92824 Q96EP4
|
| Accessions |
AFI24907 CAE75579 CAE75580 EAW62575 EAW62576 EAW62577 Q92824 AI379031 AK023096 AK056202 BAG51646 AK122718 AK225773 AK310862 AL834522 CAD39178 AM393199 CAL38077 BC012064 AAH12064 BM719207 CK023649 CN360310 DA992221 DB491139 DQ892327 ABM83253 DQ895531 ABM86457 DT932737 DV080167 DY655633 HY155058 U49114 AAA91807 U56387 AAC50643 XM_005252039 XP_005252096 XM_011518769 XP_011517071 XM_011518770 XP_011517072 XR_929806 XR_929807 NM_001190482 NP_001177411 NM_006200 NP_006191 NR_120409
|
| Function |
Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins. {ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025, ECO:0000269|PubMed:22740495}.
|
| Subcellular Location |
Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in T-lymphocytes.
|
![Western Blot: PC6 Overexpression Lysate (Adult Normal) [NBL1-14191] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for PC6.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/7782_PC6%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14191-img0002.jpg)