PCSK5

Gene Symbol PCSK5
Entrez Gene 5125
Alt Symbol PC5, PC6, PC6A, SPC6
Species Human
Gene Type protein-coding
Description proprotein convertase subtilisin/kexin type 5
Other Description prohormone convertase 5|proprotein convertase 6|protease PC6|subtilase|subtilisin/kexin-like protease PC5
Swissprots F5H2G7 Q13527 Q92824 Q96EP4
Accessions AFI24907 CAE75579 CAE75580 EAW62575 EAW62576 EAW62577 Q92824 AI379031 AK023096 AK056202 BAG51646 AK122718 AK225773 AK310862 AL834522 CAD39178 AM393199 CAL38077 BC012064 AAH12064 BM719207 CK023649 CN360310 DA992221 DB491139 DQ892327 ABM83253 DQ895531 ABM86457 DT932737 DV080167 DY655633 HY155058 U49114 AAA91807 U56387 AAC50643 XM_005252039 XP_005252096 XM_011518769 XP_011517071 XM_011518770 XP_011517072 XR_929806 XR_929807 NM_001190482 NP_001177411 NM_006200 NP_006191 NR_120409
Function Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha- integrins. {ECO:0000269|PubMed:19764806, ECO:0000269|PubMed:20555025, ECO:0000269|PubMed:22740495}.
Subcellular Location Isoform PC6A: Secreted. Note=Secreted through the regulated secretory pathway. {ECO:0000250}.
Tissue Specificity Expressed in T-lymphocytes.

PC5/6 (E-20) - sc-22901 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

PC5/6 (T-19) - sc-22900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PC6 antibody - ab40133 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab40133 stained Hek293 cells. The cells were 4% formaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab40133, 1µg/ml) overnight at +4°C. The secondary antibody (green) was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) used at a 1/1000 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-PC6 antibody - Aminoterminal end - ab39873 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PC6 antibody - N-terminal - ab156238 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-PC6 antibody - N-terminal (ab156238) at 1/100 dilution + WiDr cell line lysate at 35 µg

Anti-PC5 / PCSK5 Antibody (aa27-540) - LS-C17375 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, AP) - LS-C216641 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, APC) - LS-C216642 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, Biotin) - LS-C216643 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, FITC) - LS-C216644 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, PE) - LS-C216645 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124, Azide-free, HRP) - LS-C216646 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa95-124) - LS-C323865 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody - LS-C341796 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PC5 / PCSK5 Antibody (aa792-841) - LS-C110797 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
PCSK5 / PC5 antibody LS-C110797 Western blot of 293T cell lysate.

Anti-PC5 / PCSK5 Antibody (aa95-124) - LS-C158035 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
PCSK5 Antibody western blot of WiDr cell line lysates (35 ug/lane). The PCSK5 antibody detected the PCSK5 protein (arrow).

PC6 Antibody - NBP1-57908 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PC6 Antibody [NBP1-57908] - 293T cells lysate, concentration 0.2-1 ug/ml.

PC6 Antibody - NBP1-87326 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: PC6 Antibody [NBP1-87326] - Immunofluorescent staining of human cell line RH-30 shows localization to the Golgi apparatus.

PC6 Antibody - NBP1-46106 from Novus Biologicals

Prices $199.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-PCSK5 antibody produced in rabbit - HPA031072 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PCSK5: <B>Cat. No. HPA031072</B>: Immunohistochemical staining of human duodenum shows moderate, granular cytoplasmic positivity in glandular cells.

Anti-PCSK5 (176-190) antibody produced in rabbit - SAB1100775 from Sigma-Aldrich

Prices $328.50
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-PCSK5 (176-190) : <B>Cat. No. SAB1100775</B>: Immunofluorescence of HUVEC cells using PCSK5 (176-190) , Cat. No. SAB1100775 (red) at a 1:100 dilution, taken at 40x magnification and nuclear staining with Hoescht 33342 (blue).Yale HTCB IF procedure used. Images have been adjusted to improve viewing quality. If you would like the original image, please send a request to protocols@sial.com

Anti-PCSK5 antibody produced in rabbit - SAB2101750 from Sigma-Aldrich

Prices $347.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunoblotting</B><BR/>Anti-PCSK5: <B>Cat. No.SAB2101750</B>: PCSK5 in 293T cell lysate with PCSK5 antibody at 1.0 μg/mL.

PCSK5 antibody - middle region (ARP43530_P050) - ARP43530_P050 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PCSK5-Antibody-N-term - AP19980a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
PCSK5 Antibody (N-term) (Cat. #AP19980a) western blot analysis in WiDr cell line lysates (35ug/lane).This demonstrates the PCSK5 antibody detected the PCSK5 protein (arrow).

PCSK5-Antibody-internal-region - AF2835a from Abgent, a WuXi AppTec company

Prices $325.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
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