UACA

Gene Symbol	UACA
Entrez Gene	55075
Alt Symbol	NUCLING
Species	Human
Gene Type	protein-coding
Description	uveal autoantigen with coiled-coil domains and ankyrin repeats
Other Description	nuclear membrane binding protein|uveal autoantigen with coiled coil domains and ankyrin repeats
Swissprots	Q9NWC6 Q96NH6 Q9HCL1 Q14DD3 Q9BZF9 Q8N3B8 G3XAG2
Accessions	EAW77853 EAW77854 EAW77855 Q9BZF9 AB046781 BAB13387 AF322916 AAG49577 AK000990 BAA91457 AK055435 BAB70922 AK057207 AL834243 CAD38920 AL834464 CAD39123 BC016881 AAH16881 BC113407 AAI13408 BC113409 AAI13410 BC143266 AAI43267 BC143267 AAI43268 BM693348 BU736944 CN303461 XM_005254527 XP_005254584 XM_005254529 XP_005254586 XM_011521752 XP_011520054 XM_011521753 XP_011520055 XM_011521754 XP_011520056 NM_001008224 NP_001008225 NM_018003 NP_060473
Function	Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:15358194}. Cytoplasm {ECO:0000269|PubMed:15358194}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15358194}. Note=Expressed diffusely in cytoplasm.
Tissue Specificity	Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. {ECO:0000269|PubMed:11162650, ECO:0000269|PubMed:15358194}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UACA - MBS1269895 from MyBioSource Species Human Accession BC113407

Human UACA Gene ORF cDNA clone in cloning vector - HG13514-G from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-Flag tag - HG13514-NF from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-Myc tag - HG13514-NM from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-Flag tag - HG13514-CF from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG13514-ACG from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-Myc tag - HG13514-CM from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-HA tag - HG13514-CY from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-His tag - HG13514-NH from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG13514-ANG from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid - HG13514-UT from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-His tag - HG13514-CH from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG13514-ANR from Sino Biological Species Human

Human UACA Gene ORF cDNA clone expression plasmid, N-HA tag - HG13514-NY from Sino Biological Species Human

Human UACA ORF clone(NM_018003.2) - CDCL186659 from Creative biogene Species Human

human UACA ORF clone (NM_001008224.1) - CDCH097166 from Creative biogene Species Human

Human UACA ORF Clone (BC113407) - CDCS406349 from Creative biogene Species Human Accession G3XAG2

Human UACA cDNA Clone(NM_018003.2) - CDFG001266 from Creative biogene Species Human

Human UACA cDNA Clone(NM_001008224.1) - CDFH020704 from Creative biogene Species Human

Human UACA Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG13514-ACR from Sino Biological Species Human

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