UACA

Gene Symbol UACA
Entrez Gene 55075
Alt Symbol NUCLING
Species Human
Gene Type protein-coding
Description uveal autoantigen with coiled-coil domains and ankyrin repeats
Other Description nuclear membrane binding protein|uveal autoantigen with coiled coil domains and ankyrin repeats
Swissprots Q9NWC6 Q96NH6 Q9HCL1 Q14DD3 Q9BZF9 Q8N3B8 G3XAG2
Accessions EAW77853 EAW77854 EAW77855 Q9BZF9 AB046781 BAB13387 AF322916 AAG49577 AK000990 BAA91457 AK055435 BAB70922 AK057207 AL834243 CAD38920 AL834464 CAD39123 BC016881 AAH16881 BC113407 AAI13408 BC113409 AAI13410 BC143266 AAI43267 BC143267 AAI43268 BM693348 BU736944 CN303461 XM_005254527 XP_005254584 XM_005254529 XP_005254586 XM_011521752 XP_011520054 XM_011521753 XP_011520055 XM_011521754 XP_011520056 NM_001008224 NP_001008225 NM_018003 NP_060473
Function Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000269|PubMed:15358194}. Cytoplasm {ECO:0000269|PubMed:15358194}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:15358194}. Note=Expressed diffusely in cytoplasm.
Tissue Specificity Highly expressed in skeletal muscle, heart, kidney and pancreas. Expressed in choroid, retina and epidermal melanocytes. Expressed in eye muscles and thyroid follicular cells. {ECO:0000269|PubMed:11162650, ECO:0000269|PubMed:15358194}.

Nucling CRISPR/Cas9 KO Plasmid (h) - sc-406671 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling HDR Plasmid (h) - sc-406671-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling Double Nickase Plasmid (h) - sc-406671-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling Double Nickase Plasmid (h2) - sc-406671-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling CRISPR Activation Plasmid (h) - sc-406671-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling CRISPR Activation Plasmid (h2) - sc-406671-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling Lentiviral Activation Particles (h) - sc-406671-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling Lentiviral Activation Particles (h2) - sc-406671-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Nucling siRNA (h) - sc-90147 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nucling shRNA Plasmid (h) - sc-90147-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Nucling shRNA (h) Lentiviral Particles - sc-90147-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU057531 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN22333 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22333 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

UACA siRNA (Human) - CRJ0449 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UACA - MBS8211274 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

UACA - MBS8231581 from MyBioSource

shRNA set against Human Uaca (NM_018003.2) - SHH438600 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UACA(NM_001008224.1) - SHL109452 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human UACA(NM_018003.2) - SHL109470 from Creative biogene

Category siRNA
Species Reactivities Human

UACA shRNA Plasmid (Human) - CHJ0449 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

UACA miRNA 3'UTR clone - MiUTR1H-10919 from Creative biogene

Species Reactivities Human

UACA miRNA 3'UTR clone - MiUTR1H-10920 from Creative biogene

Species Reactivities Human
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