| Gene Symbol |
BRMS1
|
| Entrez Gene |
25855
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
breast cancer metastasis suppressor 1
|
| Other Description |
breast cancer metastasis-suppressor 1
|
| Swissprots |
Q6IAI2 Q9HCU9
|
| Accessions |
AAK69131 EAW74513 EAW74514 EAW74515 EAW74516 Q9HCU9 AF147350 AF159141 AAG00075 AI797564 AK310991 AK313773 BAG36511 AL050008 CAB43235 BC009834 AAH09834 BM312965 BU734281 CB130346 CB529276 CR457173 CAG33454 NM_001024957 NP_001020128 NM_015399 NP_056214 NM_001024958
|
| Function |
Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Predominantly nuclear.
|
| Tissue Specificity |
Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. {ECO:0000269|PubMed:12414911}.
|
