Gene Symbol | BRMS1 |
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Entrez Gene | 25855 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | breast cancer metastasis suppressor 1 |
Other Description | breast cancer metastasis-suppressor 1 |
Swissprots | Q6IAI2 Q9HCU9 |
Accessions | AAK69131 EAW74513 EAW74514 EAW74515 EAW74516 Q9HCU9 AF147350 AF159141 AAG00075 AI797564 AK310991 AK313773 BAG36511 AL050008 CAB43235 BC009834 AAH09834 BM312965 BU734281 CB130346 CB529276 CR457173 CAG33454 NM_001024957 NP_001020128 NM_015399 NP_056214 NM_001024958 |
Function | Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down- regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma. {ECO:0000269|PubMed:14581478, ECO:0000269|PubMed:17000776, ECO:0000269|PubMed:20830743}. |
Subcellular Location | Nucleus. Cytoplasm. Note=Predominantly nuclear. |
Tissue Specificity | Expression levels are higher in term placentas than in early placentas. Low levels of expression observed in normal pregnancies and in molar pregnancies. {ECO:0000269|PubMed:12414911}. |
BRMS1 (D-15) - sc-49390 from Santa Cruz Biotechnology
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BRMS1 (L-18) - sc-49391 from Santa Cruz Biotechnology
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BRMS1 (H-40) - sc-134741 from Santa Cruz Biotechnology
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BRMS1 (4H7) - sc-101219 from Santa Cruz Biotechnology
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Anti-BRMS1 antibody - ab57082 from Abcam
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Anti-BRMS1 antibody - ab65244 from Abcam
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Anti-BRMS1 antibody [EPR7202] - ab134968 from Abcam
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Anti-BRMS1 antibody [EPR7203(2)] - ab180852 from Abcam
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Anti-BRMS1 antibody - N-terminal - ab175025 from Abcam
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Anti-BRMS1 Antibody (aa21-70) IHC-plus⢠- LS-B10005 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa186-235) - LS-C151586 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, AP) - LS-C252988 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, FITC) - LS-C252991 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, APC) - LS-C252989 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, Azide-free, HRP) - LS-C252992 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, Biotin) - LS-C252990 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77) - LS-C157586 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa48-77, PE) - LS-C252993 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (clone 2D4-2G11) - LS-C306571 from LifeSpan Bioscience
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Anti-BRMS1 Antibody - LS-C309631 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (aa47-77) - LS-C319878 from LifeSpan Bioscience
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Anti-BRMS1 Antibody (N-Terminus, clone EPR7202) - LS-C154742 from LifeSpan Bioscience
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BRMS1 Antibody (2D4-2G11) - H00025855-M01 from Novus Biologicals
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BRMS1 Antibody - NBP1-85090 from Novus Biologicals
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BRMS1 Antibody - NBP1-51176 from Novus Biologicals
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