| Gene Symbol |
STIM2
|
| Entrez Gene |
57620
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
stromal interaction molecule 2
|
| Other Description |
-
|
| Swissprots |
Q96BF1 Q9BQH2 B7ZVY0 A6H8L7 Q9H8R1 Q9P246
|
| Accessions |
EAW92853 EAW92854 EAW92855 Q9P246 AB040915 BAA96006 AF328905 AAK82337 AK023369 BAB14545 AK096846 BAG53377 AL136577 CAB66512 BC015659 AAH15659 BC043604 AAH43604 BC057231 AAH57231 BC136449 AAI36450 BC146661 AAI46662 BC152554 AAI52555 BC171766 AAI71766 BU741823 BX343313 NM_001169117 NP_001162588 NM_001169118 NP_001162589 NM_020860 NP_065911
|
| Function |
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
|
| Tissue Specificity |
Expressed in all tissues and tumor cell lines examined. {ECO:0000269|PubMed:11463338}.
|
| Top Pathways |
Calcium signaling pathway
|