STIM2

Gene Symbol STIM2
Entrez Gene 57620
Alt Symbol -
Species Human
Gene Type protein-coding
Description stromal interaction molecule 2
Other Description -
Swissprots Q96BF1 Q9BQH2 B7ZVY0 A6H8L7 Q9H8R1 Q9P246
Accessions EAW92853 EAW92854 EAW92855 Q9P246 AB040915 BAA96006 AF328905 AAK82337 AK023369 BAB14545 AK096846 BAG53377 AL136577 CAB66512 BC015659 AAH15659 BC043604 AAH43604 BC057231 AAH57231 BC136449 AAI36450 BC146661 AAI46662 BC152554 AAI52555 BC171766 AAI71766 BU741823 BX343313 NM_001169117 NP_001162588 NM_001169118 NP_001162589 NM_020860 NP_065911
Function Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
Tissue Specificity Expressed in all tissues and tumor cell lines examined. {ECO:0000269|PubMed:11463338}.
Top Pathways Calcium signaling pathway

Stim2 CRISPR/Cas9 KO Plasmid (h) - sc-403491 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 HDR Plasmid (h) - sc-403491-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 Double Nickase Plasmid (h) - sc-403491-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 Double Nickase Plasmid (h2) - sc-403491-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 CRISPR Activation Plasmid (h) - sc-403491-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 CRISPR Activation Plasmid (h2) - sc-403491-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 Lentiviral Activation Particles (h) - sc-403491-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 Lentiviral Activation Particles (h2) - sc-403491-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Stim2 siRNA (h) - sc-76591 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Stim2 shRNA Plasmid (h) - sc-76591-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Stim2 shRNA (h) Lentiviral Particles - sc-76591-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU028441 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN20726 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20726 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

STIM2 siRNA (Human) - CRJ1587 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

STIM2 - MBS8211594 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human STIM2 (NM_020860.3) - SHH419652 from Creative biogene

Category siRNA
Species Reactivities Human

Human STIM2 siRNA - orb272088 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

STIM2 shRNA Plasmid (Human) - CHJ1587 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

STIM2 miRNA 3'UTR clone - MiUTR4H-TG12544 from Creative biogene

Species Reactivities Human
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