STIM2

Gene Symbol	STIM2
Entrez Gene	57620
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 2
Other Description	-
Swissprots	Q96BF1 Q9BQH2 B7ZVY0 A6H8L7 Q9H8R1 Q9P246
Accessions	EAW92853 EAW92854 EAW92855 Q9P246 AB040915 BAA96006 AF328905 AAK82337 AK023369 BAB14545 AK096846 BAG53377 AL136577 CAB66512 BC015659 AAH15659 BC043604 AAH43604 BC057231 AAH57231 BC136449 AAI36450 BC146661 AAI46662 BC152554 AAI52555 BC171766 AAI71766 BU741823 BX343313 NM_001169117 NP_001162588 NM_001169118 NP_001162589 NM_020860 NP_065911
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269|PubMed:16005298, ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041, ECO:0000269|PubMed:21217057, ECO:0000269|PubMed:22464749, ECO:0000269|PubMed:23359669}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269|PubMed:16860747, ECO:0000269|PubMed:17905723, ECO:0000269|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
Tissue Specificity	Expressed in all tissues and tumor cell lines examined. {ECO:0000269|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

STIM2 peptide - ab168330 from Abcam Category Peptide

STIM2 peptide - ab176417 from Abcam Category Peptide

STIM2 Antibody Blocking Peptide - LS-E1753 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STIM2 Antibody Blocking Peptide - LS-E30341 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STIM2 Antibody Blocking Peptide - LS-E30342 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

STIM2 Antibody Blocking Peptide - LS-E23332 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

STIM2 Blocking Peptide - NBP1-76791PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

STIM2 Peptide - NBP1-76790PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

STIM2-Antibody-N-term-Blocking-peptide - BP12545a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

STIM2 Peptide - GTX85440-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

STIM2 Peptide - GTX85441-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

STIM2 Control Peptide - AP30838CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

STIM2 Control Peptide - AP30839CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

STIM2 Peptide - 4123P from ProSci Category Peptide Species Human

STIM2 Peptide - 4125P from ProSci Category Peptide Species Human

STIM2 fusion protein - Ag15530 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

STIM2 fusion protein - Ag15949 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human STIM2, GST-tagged - STIM2-3005H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Stromal interaction molecule 2(STIM2) - CSB-YP022830HU CSB-EP022830HU CSB-BP022830HU CSB-MP022830HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

STIM2 - TP324102 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

STIM2 Recombinant Protein Antigen - NBP2-37882PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

STIM2 Recombinant Protein Antigen - NBP2-37964PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

STIM2 Peptide, Human - M34GP15300H from Creative Peptides Category Peptide Source Synthetic. Species Human

Stromal interaction molecule 2 (STIM2), Recombinant Protein - MBS1364815 from MyBioSource Category Protein Prices $955.00, $955.00, $1,175.00, $1,175.00, $1,425.00, $1,425.00, $1,890.00, $1,890.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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