STIM2

Gene Symbol	STIM2
Entrez Gene	57620
Alt Symbol	-
Species	Human
Gene Type	protein-coding
Description	stromal interaction molecule 2
Other Description	-
Swissprots	Q96BF1 Q9BQH2 B7ZVY0 A6H8L7 Q9H8R1 Q9P246
Accessions	EAW92853 EAW92854 EAW92855 Q9P246 AB040915 BAA96006 AF328905 AAK82337 AK023369 BAB14545 AK096846 BAG53377 AL136577 CAB66512 BC015659 AAH15659 BC043604 AAH43604 BC057231 AAH57231 BC136449 AAI36450 BC146661 AAI46662 BC152554 AAI52555 BC171766 AAI71766 BU741823 BX343313 NM_001169117 NP_001162588 NM_001169118 NP_001162589 NM_020860 NP_065911
Function	Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx. {ECO:0000269\|PubMed:16005298, ECO:0000269\|PubMed:16860747, ECO:0000269\|PubMed:17905723, ECO:0000269\|PubMed:18160041, ECO:0000269\|PubMed:21217057, ECO:0000269\|PubMed:22464749, ECO:0000269\|PubMed:23359669}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269\|PubMed:16860747, ECO:0000269\|PubMed:17905723, ECO:0000269\|PubMed:18160041}; Single-pass type I membrane protein {ECO:0000269\|PubMed:16860747, ECO:0000269\|PubMed:17905723, ECO:0000269\|PubMed:18160041}. Note=Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.
Tissue Specificity	Expressed in all tissues and tumor cell lines examined. {ECO:0000269\|PubMed:11463338}.
Top Pathways	Calcium signaling pathway

STIM2 Antibody - 4917 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from various cell lines using STIM2 Antibody.

Stim2 (N-18) - sc-79110 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Stim2 (N-18): sc-79110. Western blot analysis of Stim2 expression in non-transfected: sc-117752 (A) and human Stim2 transfected: sc-112654 (B) 293T whole cell lysates.

Stim2 (H-300) - sc-292638 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

Stim2 (D-20) - sc-79108 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Stim2 (S-20) - sc-79111 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Stim2 (S-20): sc-79111. Western blot analysis of Stim2 expression in Y79 (A), PC-12 (B) and NIH/3T3 (C) whole cell lysates and mouse pancreas tissue extract (D).

Anti-STIM2 antibody - ab59342 from Abcam

Prices	$388.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Lane 1 : Anti-STIM2 antibody (ab59342) at 0.5 µg/mlLane 2 : Anti-STIM2 antibody (ab59342) at 1 µg/mlLane 3 : Anti-STIM2 antibody (ab59342) at 2 µg/mlLane 1 : A-20 cell lysateLane 2 : A-20 cell lysateLane 3 : A-20 cell lysateLysates/proteins at 15 µg per lane.

Anti-STIM2 antibody - ab83792 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 antibody - ab112963 from Abcam

Prices	$376.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 antibody (ab112963) at 1/100 dilution + UM cell line lysate at 35 µg

Anti-STIM2 antibody [EPR12879] - C-terminal - ab181258 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR12879

All lanes : Anti-STIM2 antibody [EPR12879] - C-terminal (ab181258) at 1/10000 dilutionLane 1 : A673 cell lysateLane 2 : BxPC3 cell lysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugated) at 1/1000 dilution

Anti-STIM2 antibody - C-terminal - ab157667 from Abcam

Prices	$376.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 antibody - C-terminal (ab157667) at 1 µg/ml + mouse pancreas lysate at 10 µg

Anti-STIM2 Antibody (Internal) IHC-plus™ - LS-B3210 from LifeSpan Bioscience

Prices	$395.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B3210 concentration 5 ug/ml.

Anti-STIM2 Antibody (N-Terminus) - LS-C209379 from LifeSpan Bioscience

Prices	$395.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, APC) - LS-C224183 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, AP) - LS-C224184 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa663-712) - LS-C170406 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, Biotin) - LS-C224185 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, Azide-free, HRP) - LS-C224187 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, FITC) - LS-C224186 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127, PE) - LS-C224188 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127) - LS-C325447 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa600-650) - LS-C291065 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human and Mouse STIM2 by Western Blot. Samples: Whole cell lysate (50 ug) prepared using NETN buffer from HeLa, 293T, Jurkat, mouse TCMK-1, and mouse NIH3T3 cells. Antibodies: Affinity purified rabbit anti-STIM2 antibody used for WB at 0.1 ug/ml. Detection: Chemiluminescence with an exposure time of 3 minutes.

Anti-STIM2 Antibody - LS-C187739 from LifeSpan Bioscience

Prices	$310.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry of formalin-fixed, paraffin-embedded human spleen stained with Rabbit anti-Human STIM2 following heat mediated antigen retrieval using sodium citrate buffer (pH6.0)

Anti-STIM2 Antibody (aa650-700) - LS-C291066 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 Antibody (aa97-127) IHC-plus™ - LS-B9326 from LifeSpan Bioscience

Prices	$395.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-STIM2 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-STIM2 Antibody - LS-C346362 from LifeSpan Bioscience

Prices	$305.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

Western blot blot of extracts of HeLa cell line, using STIM2 antibody.

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