IRGM

Gene Symbol IRGM
Entrez Gene 345611
Alt Symbol IFI1, IRGM1, LRG-47, LRG47
Species Human
Gene Type protein-coding
Description immunity-related GTPase family, M
Other Description LPS-stimulated RAW 264.7 macrophage protein 47 homolog|LRG-47-like protein|immunity-related GTPase family M protein|immunity-related GTPase family, M1|interferon-inducible protein 1
Swissprots B3VEX0 A1A4Y4
Accessions A1A4Y4 ACO88909 BAJ13476 BAJ13477 BC038539 BC128167 AAI28168 BC128168 AAI28169 EU742619 ACF21844 XM_011537641 XP_011535943 XR_944324 NM_001145805 NP_001139277
Function Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity). {ECO:0000250}.
Subcellular Location Golgi apparatus membrane {ECO:0000250}. Cell membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Cytoplasmic vesicle, autophagosome membrane {ECO:0000250}. Cell projection, phagocytic cup {ECO:0000250}. Note=Behaves like an integral membrane protein. Recruited to the plasma membrane around forming phagocytic cups, it remains associated with maturing autophagosomes. Preferentially associated with cis- and medial-Golgi. {ECO:0000250}.
Tissue Specificity Widely expressed (at protein level). Expressed in several tissues including colon, small bowel and peripheral blood leukocytes. {ECO:0000269|PubMed:16888103, ECO:0000269|PubMed:17554261}.
Top Pathways Toxoplasmosis

IRGM overexpression lysate - LY429013 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

IRGM Overexpression Lysate (Native) - NBP2-09763 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: IRGM Overexpression Lysate (Adult Normal) [NBP2-09763] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for IRGM.

Panoply™ Human IRGM Knockdown Stable Cell Line - CSC-DC007748 from Creative biogene

Category Cell Line
Species Human
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